Literature summary for 6.3.2.51 extracted from

Balibar, C.J.; Hollis-Symynkywicz, M.F.; Tao, J.
Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa (2011), J. Bacteriol., 193, 3304-3312.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (R)-4'-phosphopantothenate + L-cysteine	Escherichia coli	-	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?
ATP + (R)-4'-phosphopantothenate + L-cysteine	Pseudomonas aeruginosa	-	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?
ATP + (R)-4'-phosphopantothenate + L-cysteine	Escherichia coli K-1	-	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Escherichia coli K-1	-	-	-
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (R)-4'-phosphopantothenate + L-cysteine	-	Escherichia coli	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?
ATP + (R)-4'-phosphopantothenate + L-cysteine	-	Pseudomonas aeruginosa	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?
ATP + (R)-4'-phosphopantothenate + L-cysteine	-	Escherichia coli K-1	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
CoaB	-	Escherichia coli
CoaB	-	Pseudomonas aeruginosa
phosphopantothenoylcysteine synthetase	-	Escherichia coli
phosphopantothenoylcysteine synthetase	-	Pseudomonas aeruginosa
PPCS	-	Escherichia coli
PPCS	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)