Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
axon | peripheral axon | Mus musculus | 30424 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
TTL | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | tubulin-tyrosine ligase TTL is required to increase the levels of tyrosinated alpha-tubulin at an axon injury site and plays an important role in injury signaling. Preventing the injury-induced increase in tyrosinated alpha-tubulin by knocking down TTL impairs retrograde organelle transport and delays activation of the pro-regenerative transcription factor c-Jun. In the absence of TTL, axon regeneration is reduced severely | Mus musculus |