Information on EC 6.3.2.25 - tubulin-tyrosine ligase

for references in articles please use BRENDA:EC6.3.2.25
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IUBMB Comments
L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyromega-alpha-tubulin). The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine. L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
Synthetase, tubulin-tyrosine, TTL, TTLase, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin-tyrosine-ligase, Tubulin:tyrosine ligase, tubuline-tyrosine ligase, Tyrosyltubulin ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate
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