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Literature summary for 5.6.2.2 extracted from

  • Jeankumar, V.U.; Reshma, R.S.; Janupally, R.; Saxena, S.; Sridevi, J.P.; Medapi, B.; Kulkarni, P.; Yogeeswari, P.; Sriram, D.
    Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain lead optimization and structure activity profiling (2015), Org. Biomol. Chem., 13, 2423-2431 .
    View publication on PubMed
Search for more literature for 5.6.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) pLysS cells Mycolicibacterium smegmatis
expressed in Escherichia coli BL21 (DE3) pLysS cells Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-2-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-(pyridin-3-yl)thiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycobacterium tuberculosis
4-((1-(7-methoxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-5-yl)methoxy)-2-phenylthiazole-5-carboxylic acid
-
 Mycolicibacterium smegmatis
4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-[[1-(2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-[[1-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-1H-1,2,3-triazol-5-yl]methoxy]-2-(pyridin-2-yl)-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-4,5-dihydro-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycobacterium tuberculosis
4-[[1-(7-methoxy-2-oxo-2H-1-benzopyran-3-yl)-4,5-dihydro-1H-1,2,3-triazol-5-yl]methoxy]-2-phenyl-1,3-thiazole-5-carboxamide
-
 Mycolicibacterium smegmatis
novobiocin
-
 Mycobacterium tuberculosis
novobiocin
-
 Mycolicibacterium smegmatis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-
Mycolicibacterium smegmatis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Mycolicibacterium smegmatis
Ni-NTA column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + supercoiled pBR322 DNA
-
 Mycolicibacterium smegmatis ADP + phosphate + relaxed pBR322 DNA
-
 ?
ATP + supercoiled pBR322 DNA
-
 Mycobacterium tuberculosis ADP + phosphate + relaxed pBR322 DNA
-
 ?
ATP + supercoiled pBR322 DNA
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + relaxed pBR322 DNA
-
 ?

Synonyms

Synonyms Comment Organism
DNA gyrase
-
 Mycolicibacterium smegmatis
DNA gyrase
-
 Mycobacterium tuberculosis
GyrB
-
 Mycolicibacterium smegmatis
GyrB
-
 Mycobacterium tuberculosis
type II topoisomerase
-
 Mycolicibacterium smegmatis
type II topoisomerase
-
 Mycobacterium tuberculosis