Literature summary for 5.6.2.2 extracted from

Plech, T.; Kapro?, B.; Paneth, A.; Wujec, M.; Czarnomysy, R.; Bielawska, A.; Bielawski, K.; Trotsko, N.; Ku?mierz, E.; Paneth, P.
Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles (2015), J. Enzyme Inhib. Med. Chem., 30, 1021-1026 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(3-fluorophenylamino)-5-(3-hydroxyphenyl)-1,3,4-thiadiazole	DNA topoisomerase II catalytic inhibitor	Homo sapiens
2-(4-bromophenylamino)-5-(2,4-dichlorophenyl)-1,3,4-thiadiazole	DNA topoisomerase II poison	Homo sapiens
2-(4-fluorophenylamino)-5-(2,4-dichlorophenyl)-1,3,4-thiadiazole	DNA topoisomerase II poison	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase II	-	Homo sapiens
TOPOII	-	Homo sapiens

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Release 2023.1 (January 2023)