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Literature summary for 5.6.2.2 extracted from

  • Alam, S.; Khan, F.
    QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIalpha (2014), Drug Des. Devel. Ther., 8, 183-195.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-(2-hydroxypropan-2-yl)-2,5-dimethyl-8,10-bis[(2-methyloxiran-2-yl)methoxy]-1,2-dihydro-11H-furo[3,2-a]xanthen-11-one
-
 Homo sapiens
1,3,5-trihydroxy-4-methoxy-9H-xanthen-9-one
-
 Homo sapiens
1,5-dihydroxy-3-methoxy-2,4-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
-
 Homo sapiens
1,7-dihydroxy-9H-xanthen-9-one
-
 Homo sapiens
5,8-dihydroxy-4-methoxy-3,6-bis(3-methylbut-2-en-1-yl)-4a,9a-dihydro-1H-xanthene-1,2,9-trione
-
 Homo sapiens
5-methoxy-1,3-bis[(2-methyloxiran-2-yl)methoxy]-7-(oxiran-2-ylmethyl)-9H-xanthen-9-one
-
 Homo sapiens
5-methoxy-1,3-bis[(2-methyloxiran-2-yl)methoxy]-7-(propan-2-yl)-9H-xanthen-9-one
-
 Homo sapiens
6,11-dihydroxy-3,3-dimethyl-5-(3-methylbut-2-en-1-yl)-3H,7H-pyrano[2,3-c]xanthen-7-one
-
 Homo sapiens
additional information xanthone derivative inhibitor design, pharmacokinet­ics parameters , and structure-activity relationship represented by the QSAR model, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
deoxyribonucleic acid topoisomerase IIalpha
-
 Homo sapiens
DNA topoisomerase IIalpha
-
 Homo sapiens
DNATop2A
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00058
-
 pH and temperature not specified in the publication Homo sapiens 1,7-dihydroxy-9H-xanthen-9-one
0.00058
-
 pH and temperature not specified in the publication Homo sapiens 1,3,5-trihydroxy-4-methoxy-9H-xanthen-9-one
0.0006
-
 pH and temperature not specified in the publication Homo sapiens 6,11-dihydroxy-3,3-dimethyl-5-(3-methylbut-2-en-1-yl)-3H,7H-pyrano[2,3-c]xanthen-7-one
0.00069
-
 pH and temperature not specified in the publication Homo sapiens 1,5-dihydroxy-3-methoxy-2,4-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
0.00071
-
 pH and temperature not specified in the publication, predicted value Homo sapiens 5,8-dihydroxy-4-methoxy-3,6-bis(3-methylbut-2-en-1-yl)-4a,9a-dihydro-1H-xanthene-1,2,9-trione
0.00075
-
 pH and temperature not specified in the publication, predicted value Homo sapiens 5-methoxy-1,3-bis[(2-methyloxiran-2-yl)methoxy]-7-(propan-2-yl)-9H-xanthen-9-one
0.00079
-
 pH and temperature not specified in the publication, predicted value Homo sapiens 5-methoxy-1,3-bis[(2-methyloxiran-2-yl)methoxy]-7-(oxiran-2-ylmethyl)-9H-xanthen-9-one
0.00083
-
 pH and temperature not specified in the publication, predicted value Homo sapiens (2S)-2-(2-hydroxypropan-2-yl)-2,5-dimethyl-8,10-bis[(2-methyloxiran-2-yl)methoxy]-1,2-dihydro-11H-furo[3,2-a]xanthen-11-one