Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-N-(2-pyrazinecarboxylic) amino-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-N-(3,4,5-trihydroxybenzoic) amino-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-N-(5-methylpyrazine-2-carboxylic)amino-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-N-(theophylline-7-acetic) amino-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-O-(2-quinoline carboxylic)-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-O-(5-methylpyrazine-2-carboxylic)-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-O-(fluoroquinolonic)-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
4-O-(theophylline-7-acetic)-4'-demethylepipodophyllotoxin | - |
Homo sapiens | |
additional information | rational design strategy of podophyllum topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation, overview. The compounds exhibit promising in vitro antitumor activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
topo II | - |
Homo sapiens |
Topoisomerase II | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
cytotoxic activity of inhibitory compounds, docking study, overview | Homo sapiens | additional information |