Inhibitors | Comment | Organism | Structure |
---|---|---|---|
etoposide | VP-16, induces skin melanomas formation in 7,12-dimethyl-benz[a]anthracene-initiated mice | Mus musculus | |
nitric oxide | NO, unlike VP-16, preferentially induces the formation of TOP2beta cleavable complexes in cells, induces skin melanomas formation in 7,12-dimethyl-benz[a]anthracene-initiated mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanoma cell | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Top2 | - |
Mus musculus |
Topoisomerase II | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | topoisomerase II isozymes contribute to NO-induced mutagenesis and subsequent cancer development during chronic inflammation. mechanism, overview | Mus musculus |