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Literature summary for 5.6.2.2 extracted from

  • Bhanu, M.U.; Mandraju, R.K.; Bhaskar, C.; Kondapi, A.K.
    Cultured cerebellar granule neurons as an in vitro aging model: topoisomerase IIbeta as an additional biomarker in DNA repair and aging (2010), Toxicol. In Vitro, 24, 1935-1945.
    View publication on PubMed
Search for more literature for 5.6.2.2

Application

Application Comment Organism
diagnostics topoisomerase IIbeta acts as an additional biomarker in DNA repair and aging in cerebellar granule neurons, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 isozyme topo IIbeta
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isozyme topoisomerase IIbeta Rattus norvegicus
-
neuron primary cerebellar granule neurons, isozyme topoisomerase IIbeta Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozyme topo IIbeta substrate is plasmid DNA Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Topo IIbeta
-
 Rattus norvegicus
topoisomerase IIbeta
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus