Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aclarubicin | inhibits enzyme binding to the DNA substrate | Homo sapiens | |
Benzene | enzyme inhibition by benzene and its metabolites represents a potential mechanism by which benzene can induce its chromosome-altering and leukemogenic effects | Homo sapiens | |
etoposide | inhibits ADP and T segment release | Homo sapiens | |
hydroquinone | hydroquinone inhibits topoII at the DNA binding stage as well as in the closed clamp stage in the catalytic cycle, thereby interfering with either the binding to, or the release of, DNA from the enzyme, inhibition mechanism, overview | Homo sapiens | |
ICRF 187 | inhibits ATP hydrolysis | Homo sapiens | |
ICRF 193 | inhibits ATP hydrolysis | Homo sapiens | |
Merbarone | inhibits, ATP binding, dimerization and DNA double strand break, and thus stabilization of the DNA-enzyme complex | Homo sapiens | |
additional information | inhibitor binding and inhibition mechanisms, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalytic cycle of topoisomerase II, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
topIIalpha | - |
Homo sapiens |
TOPOII | - |
Homo sapiens |
Topoisomerase II | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |