Literature summary for 5.6.2.2 extracted from

Coelho, P.A.; Queiroz-Machado, J.; Carmo, A.M.; Moutinho-Pereira, S.; Maiato, H.; Sunkel, C.E.
Dual role of topoisomerase II in centromere resolution and Aurora B activity (2008), PLoS Biol., 6, e207.

Search for more literature for 5.6.2.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	TOPO II is required to promote Aurora B kinase activity	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Drosophila melanogaster	topoisomerase II ensures proper sister chromatid separation through a direct role in centromere resolution and prevents incorrect microtubule-kinetochore attachments by allowing proper activation of Aurora B kinase, TOPO II activity is required to establish amphitelic kinetochore attachment, TOPO II is required for centromere separation independently of the cohesin complex	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
S2 cell	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	topoisomerase II ensures proper sister chromatid separation through a direct role in centromere resolution and prevents incorrect microtubule-kinetochore attachments by allowing proper activation of Aurora B kinase, TOPO II activity is required to establish amphitelic kinetochore attachment, TOPO II is required for centromere separation independently of the cohesin complex	Drosophila melanogaster	?	-	?
supercoiled DNA + ATP + H2O	-	Drosophila melanogaster	catenated DNA networks + ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
topo II	-	Drosophila melanogaster
Topoisomerase II	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Drosophila melanogaster

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Release 2023.1 (January 2023)