Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FEITPEKNPQ | inhibits human topoisomerase II activity through binding to the active site of the CTD domain | Homo sapiens | |
IETWNPNNKP | inhibits human topoisomerase II activity through binding to the active site of the CTD domain | Homo sapiens | |
additional information | soy protein hydrolysate inhibits 61% of topoisomerase II activity at 0.5 mg/ml | Homo sapiens | |
VFDGEL | inhibits human topoisomerase II activity through binding to the active site of the CTD domain | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
supercoiled DNA + ATP + H2O | - |
Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
topoisomerase IIalpha | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
2.4 | - |
in 50 mM Tris-HCl (pH 8.0) | Homo sapiens | FEITPEKNPQ | |
4 | - |
in 50 mM Tris-HCl (pH 8.0) | Homo sapiens | IETWNPNNKP | |
7.9 | - |
in 50 mM Tris-HCl (pH 8.0) | Homo sapiens | VFDGEL |