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Literature summary for 5.6.2.2 extracted from

  • Akasaka, T.; Kurosaka, S.; Uchida, Y.; Tanaka, M.; Sato, K.; Hayakawa, I.
    Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases (1998), Antimicrob. Agents Chemother., 42, 1284-1287.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
Sitafloxacin
-
 Escherichia coli
Sitafloxacin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
network of DNA rings + ATP + H2O decatenation Escherichia coli monomeric DNA circles + ADP + phosphate
-
 ?
network of DNA rings + ATP + H2O decatenation Homo sapiens monomeric DNA circles + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O catenation Escherichia coli catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O catenation Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O relaxation Escherichia coli relaxed DNA + ADP + phosphate
-
 ?
supercoiled DNA + ATP + H2O relaxation Homo sapiens relaxed DNA + ADP + phosphate
-
 ?