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Literature summary for 5.6.2.2 extracted from
- Yeast DNA topoisomerase II (1982), J. Biol. Chem., 257, 5866-5872.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| coumermycin | - |
Saccharomyces cerevisiae |  |
| additional information | no inhibition by nalidixic acid, oxolinic acid or novobiocin | Saccharomyces cerevisiae |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | decatenation reaction proceedes efficiently only at concentrations above 150 mM KCl | Saccharomyces cerevisiae | |
| Mg2+ | required | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | does not catalyze DNA supercoiling | Saccharomyces cerevisiae | ? | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Saccharomyces cerevisiae | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | in absence of an DNA-binding protein: decatenation and unknotting of the DNA rings | Saccharomyces cerevisiae | monomeric DNA circles + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | network of DNA rings that are topologically interlocked | ? | |
| supercoiled DNA + ATP + H2O | in presence of a yeast DNA-binding protein | Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | network of DNA rings that are topologically interlocked | ? | |
| supercoiled DNA + ATP + H2O | covalently closed double-stranded DNA rings | Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | network of DNA rings that are topologically interlocked | ? | |
| supercoiled DNA + ATP + H2O | relaxation | Saccharomyces cerevisiae | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | Saccharomyces cerevisiae | relaxed DNA + ADP + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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