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Literature summary for 5.6.1.6 extracted from
- Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator (2018), J. Biol. Chem., 293, 17685-17704 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| mutant enzyme F508del, microbatch method, using 40% (w/v) PEG 400, 100 mM NH4Cl, and 100 mM MES, pH 6.0 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| F508del | the in-frame deletion causes cystic fibrosis | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | Homo sapiens | - |
ADP + phosphate + open Cl- channel | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P13569 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography and gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-methyl-dCTP + H2O + closed Cl- channel | - |
Homo sapiens | 5-methyl-dCDP + phosphate + open Cl- channel | - |
? | |
| 7-methyl-GTP + H2O + closed Cl- channel | - |
Homo sapiens | 7-methyl-GDP + phosphate + open Cl- channel | - |
? | |
| ATP + H2O + closed Cl- channel | - |
Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
| CTP + H2O + closed Cl- channel | - |
Homo sapiens | CDP + phosphate + open Cl- channel | - |
? | |
| dATP + H2O + closed Cl- channel | - |
Homo sapiens | dADP + phosphate + open Cl- channel | - |
? | |
| dCTP + H2O + closed Cl- channel | - |
Homo sapiens | dCDP + phosphate + open Cl- channel | - |
? | |
| dGTP + H2O + closed Cl- channel | - |
Homo sapiens | dGDP + phosphate + open Cl- channel | - |
? | |
| dTTP + H2O + closed Cl- channel | - |
Homo sapiens | dTDP + phosphate + open Cl- channel | - |
? | |
| dUTP + H2O + closed Cl- channel | - |
Homo sapiens | dUDP + phosphate + open Cl- channel | - |
? | |
| GTP + H2O + closed Cl- channel | - |
Homo sapiens | GDP + phosphate + open Cl- channel | - |
? | |
| TTP + H2O + closed Cl- channel | - |
Homo sapiens | TDP + phosphate + open Cl- channel | - |
? | |
| UTP + H2O + closed Cl- channel | - |
Homo sapiens | UDP + phosphate + open Cl- channel | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CFTR | - |
Homo sapiens |
| cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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