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Literature summary for 5.6.1.6 extracted from

  • Tu, J.; Le, G.; Ballard, H.J.
    Involvement of the cystic fibrosis transmembrane conductance regulator in the acidosis-induced efflux of ATP from rat skeletal muscle (2010), J. Physiol., 588, 4563-4578.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
CFTRinh-172 acidosis-induced ATP efflux from the perfused muscle is abolished by inhibitor CFTRinh-172 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
intestinal epithelium
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 Rattus norvegicus
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additional information no expression in intestine Rattus norvegicus
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skeletal muscle infusion of lactic acid to the perfused hindlimb muscles of anaesthetised rats produces dose-dependent decreases in pH and increases in the interstitial ATP of extensor digitorum longus muscle. Acidosis-induced ATP efflux from the perfused muscle is abolished by inhibitor CFTRinh-172, or glibenclamide. Silencing of the CFTR gene using an siRNA abolishes the acidosis-induced increase inATP release from cultured myoblasts Rattus norvegicus
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General Information

General Information Comment Organism
physiological function depression of the intracellular pH of skeletal muscle cells stimulates ATP efflux, and CFTR plays an important role in the release mechanism Rattus norvegicus