Protein Variants | Comment | Organism |
---|---|---|
E1371Q | mutation in nucleotide-binding domain 2, prevents ATP hydrolysis without affecting ATP binding and stabilizes the open state of the channel by almost 1000fold | Homo sapiens |
I331C | modification rate by methanethiosulfonate ethyl ammonium and (2-sulfonatoethyl) methanethiosulfonate is slower in the open state than in the closed state | Homo sapiens |
K335C | modification rate by methanethiosulfonate ethyl ammonium and (2-sulfonatoethyl) methanethiosulfonate is slower in the open state than in the closed state | Homo sapiens |
L333C | modification rate by methanethiosulfonate ethyl ammonium and (2-sulfonatoethyl) methanethiosulfonate is slower in the open state than in the closed state | Homo sapiens |
additional information | construction of 26 Cys-substituted mutant and analysis of change in cAMP-activated whole cell conductance | Homo sapiens |
R334C | modification rate by methanethiosulfonate ethyl ammonium and (2-sulfonatoethyl) methanethiosulfonate is not dependent on open/closed state | Homo sapiens |
T338C | modification rate by methanethiosulfonate ethyl ammonium and (2-sulfonatoethyl) methanethiosulfonate is slower in the open state than in the closed state | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform CFTR | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | ATP binding induces a modest conformational change in the sixth transmembrane segment, and this conformational change is coupled to the gating mechanism that regulates ion conduction | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? |