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Literature summary for 5.6.1.6 extracted from
- A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells (2004), J. Ethnopharmacol., 93, 351-357.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| forskolin | stimulates Cl- currents | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | SB-300, which targets the CFTR Cl- channel, is a low cost extract from Croton lechleri and may present a complementary and alternative medicine approach for the treatment of fluid loss in watery diarrhea | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| detergent SB-300 | blocks forskolin-stimulated CFTR Cl- secretion by 92.2% | Homo sapiens | |
| detergent SB-303 | decreases stimulated CFTR Cl- currents by 98% | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colonic epithelium | - |
Homo sapiens | - |
| T-84 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CFTR | - |
Homo sapiens |
| cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |
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