Application | Comment | Organism |
---|---|---|
medicine | the finding that the disassembly of the 26S proteasome is an old-age event could explain the presence of protein deposits containing ubiquitinated proteins and oxidatively modified proteins in nonpathologic aging, as well as in a variety of aging-related neurodegenerative disorders | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | a decline in proteasome activity with the aging process is shown | Drosophila melanogaster | |
PSI | proteasome inhibitor | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | Drosophila melanogaster | - |
ADP + phosphate + unfolded polypeptide | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | - |
Drosophila melanogaster | ADP + phosphate + unfolded polypeptide | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
26S proteasome | - |
Drosophila melanogaster |
proteasome ATPase | - |
Drosophila melanogaster |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
in-gel proteasome activity assay | Drosophila melanogaster |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
in-gel proteasome activity assay | Drosophila melanogaster |