Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | Saccharomyces cerevisiae | ATP hydrolysis is required for degradation of polyubiquitinated proteins by the 26S proteasome. ATP hydrolysis triggers rapid dissociation of the 19S regulatory particles from immunopurified 26S complexes in a manner coincident with release of the bulk of proteasome-interacting proteins. A controlled dissociation of the 19S regulatory particles from the 26S proteasome is part of the mechanism of protein degradation | ADP + phosphate + unfolded polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | ATP hydrolysis is required for degradation of polyubiquitinated proteins by the 26S proteasome. ATP hydrolysis triggers rapid dissociation of the 19S regulatory particles from immunopurified 26S complexes in a manner coincident with release of the bulk of proteasome-interacting proteins. A controlled dissociation of the 19S regulatory particles from the 26S proteasome is part of the mechanism of protein degradation | Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? |