Literature summary for 5.6.1.1 extracted from

Iwaya, N.; Akiyama, K.; Goda, N.; Tenno, T.; Fujiwara, Y.; Hamada, D.; Ikura, T.; Shirakawa, M.; Hiroaki, H.
Effect of Ca2+ on the microtubule-severing enzyme p60-katanin. Insight into the substrate-dependent activation mechanism (2012), FEBS J., 279, 1339-1352.

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Cloned(Commentary)

Cloned (Comment)	Organism
adaptor-p80 fragments expressed in Escherichia coli BL21(DE3), GST tagged p60-katanin expressed in Escherichia coli JM109	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
K255A	no ATPase activity	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
Ca2+	inhibits microtuble severing activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9WV86	-	-

Purification (Commentary)

Purification (Comment)	Organism
GST tagged p60-katanin purified using glutathione-Sepharose	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	binding of either microtuble or C-terminal domain of adaptor-p80 stimulates the ATPase activity of p60-katanin	Mus musculus	ADP + phosphate	-	?

Subunits

Subunits	Comment	Organism
heterodimer	p60-katanin (hexameric ring), adaptor-p80	Mus musculus

Synonyms

Synonyms	Comment	Organism
katanin	-	Mus musculus
P60-katanin	-	Mus musculus

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Release 2023.1 (January 2023)