Literature summary for 4.2.3.13 extracted from

Alchanati, I.; Acreman Patel, J.A.; Liu, J.; Benedict, C.R.; Stipanovic, R.D.; Bell, A.A.; Cui, Y.; Magill, C.W.
The enzymatic cyclization of nerolidyl diphosphate by delta-cadinene synthase from cotton stele tissue infected with Verticillium dahlia (1998), Phytochemistry, 47, 961-967.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	Gossypium barbadense	the product (+)-delta-cadinene is metabolically converted to deoxyhemigossypol, deoxyhemigossypol 6-methyl ether, hemigossypol and hemigossypol 6-methyl ether	(+)-delta-cadinene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Gossypium barbadense	-	cv. Seabrook 12B2	-
Gossypium barbadense	-	sea island cotton	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
stele	infected with Verticillium dahliae. Verticillium dahliae initiates a signal in the stele tissue that results in an increased steady-state level of delta-cadinene synthase mRNA and an increased activity of delta-cadinene synthase	Gossypium barbadense	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	nerolidyl diphosphate is an intermediate	Gossypium barbadense	(+)-delta-cadinene + diphosphate	-	?
2-trans,6-trans-farnesyl diphosphate	the product (+)-delta-cadinene is metabolically converted to deoxyhemigossypol, deoxyhemigossypol 6-methyl ether, hemigossypol and hemigossypol 6-methyl ether	Gossypium barbadense	(+)-delta-cadinene + diphosphate	-	?
nerolidyl diphosphate	-	Gossypium barbadense	(+)-delta-cadinene + diphosphate	-	?

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Release 2023.1 (January 2023)