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(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + germacradien-4-ol + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
delta-cadinene + diphosphate
(2E,6E)-farnesyl diphosphate + H2O
delta-cadinene + diphosphate
(2E,6Z)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
nerolidyl diphosphate
(+)-delta-cadinene + alpha-bisabolol + beta-bisabolene + beta-farnesene + ?
-
-
?
nerolidyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
additional information
?
-
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
products are about 60% (-)-alpha-copaene, 40% (+)-delta-cadinene
-
?
(2E,6E)-farnesyl diphosphate
delta-cadinene + diphosphate
-
-
major product
-
?
(2E,6E)-farnesyl diphosphate
delta-cadinene + diphosphate
-
-
major product
-
?
(2E,6E)-farnesyl diphosphate
delta-cadinene + diphosphate
-
delta-cadinene is one of the two main products, while alpha-muuorlene, beta-caryophyllene, alpha-humulene and alpha-copaene are minor products
-
?
(2E,6E)-farnesyl diphosphate
delta-cadinene + diphosphate
-
bifunctional sesquiterpene synthase producing both alpha-copaene and delta-cadinene
-
?
(2E,6E)-farnesyl diphosphate + H2O
delta-cadinene + diphosphate
-
Cop4 generates a tertiary cadinyl cation which upon deprotonation yields its major cyclization product delta-cadinene. The cadinyl cation reacts further to yield other cyclization products (beta-cubebene, cubebol , beta-copaene, sativene)
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
delta-cadinene + diphosphate
-
Cop4 generates a tertiary cadinyl cation which upon deprotonation yields its major cyclization product delta-cadinene. The cadinyl cation reacts further to yield other cyclization products (beta-cubebene, cubebol , beta-copaene, sativene)
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
the fungal-elicited production of a (+)-delta-cadinene synthase is consistent with a role for this enzyme as the first committed step in the pathways leading to the related phytoalexins gossypol and lacinilene C in cotton
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
amount of enzyme does not increase significantly in stems treated with Verticillium dahliae due to a high basal level of enzyme in untreated stems
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the enzyme is encoded by a complex gene family that based on homology can be divided into two subfamilies, cad1-A and cad1-C
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
nerolidyl diphosphate is an intermediate
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the first step enzyme in the conversion of farnesyl diphosphate to sesquiterpene phytoalexins. The reaction is induced by the infection of cotton with Verticillium dahliae
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the product (+)-delta-cadinene is metabolically converted to deoxyhemigossypol, deoxyhemigossypol 6-methyl ether, hemigossypol and hemigossypol 6-methyl ether
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
transcription of cad1-C is activated in stems treated with Verticillium dahliae
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the sesquiterpenoid (+)-alpha-cadinene is an intermediate in phytoalexin biosynthesis
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the enzyme is encoded by a complex gene family that based on homology can be divided into two subfamilies, cad1-A and cad1-C
-
?
additional information
?
-
delta-cadinene synthase is a sesquiterpene cyclase that utilises the universal achiral precursor farnesyl diphosphate (FDP) to generate predominantly the bicyclic sesquiterpene delta-cadinene and about 2% germacradien-4-ol
-
-
?
additional information
?
-
-
products (in vivo expression in Saccharomyces cerevisiae): delta-cadinene and a compound with a cadinene skeleton, minor products: alpha-muurolene, beta-caryophyllene, alpha-humulene and alpha-copaene
-
?
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(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + germacradien-4-ol + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
additional information
?
-
delta-cadinene synthase is a sesquiterpene cyclase that utilises the universal achiral precursor farnesyl diphosphate (FDP) to generate predominantly the bicyclic sesquiterpene delta-cadinene and about 2% germacradien-4-ol
-
-
?
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
the fungal-elicited production of a (+)-delta-cadinene synthase is consistent with a role for this enzyme as the first committed step in the pathways leading to the related phytoalexins gossypol and lacinilene C in cotton
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
amount of enzyme does not increase significantly in stems treated with Verticillium dahliae due to a high basal level of enzyme in untreated stems
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the enzyme is encoded by a complex gene family that based on homology can be divided into two subfamilies, cad1-A and cad1-C
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the first step enzyme in the conversion of farnesyl diphosphate to sesquiterpene phytoalexins. The reaction is induced by the infection of cotton with Verticillium dahliae
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the product (+)-delta-cadinene is metabolically converted to deoxyhemigossypol, deoxyhemigossypol 6-methyl ether, hemigossypol and hemigossypol 6-methyl ether
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
-
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
transcription of cad1-C is activated in stems treated with Verticillium dahliae
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the sesquiterpenoid (+)-alpha-cadinene is an intermediate in phytoalexin biosynthesis
-
?
2-trans,6-trans-farnesyl diphosphate
(+)-delta-cadinene + diphosphate
-
the enzyme is encoded by a complex gene family that based on homology can be divided into two subfamilies, cad1-A and cad1-C
-
?
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0.00058 - 0.0184
(2E,6E)-farnesyl diphosphate
0.0024 - 0.043
(2E,6Z)-farnesyl diphosphate
0.0017 - 0.0106
2-trans,6-trans-farnesyl diphosphate
0.00065
nerolidyl diphosphate
pH 7.5, 30ºC, recombinant CDN1-C1 enzyme
additional information
additional information
Michaelis-Menten steady-state kinetics, overview
-
0.00058
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 7.5 and 25°C
0.00058
(2E,6E)-farnesyl diphosphate
recombinant His6-tagged wild-type enzyme, pH 7.5, 25°C
0.00145
(2E,6E)-farnesyl diphosphate
mutant enzyme W279E, at pH 7.5 and 25°C
0.00145
(2E,6E)-farnesyl diphosphate
recombinant mutant W279E, pH 7.5, 25°C
0.0019
(2E,6E)-farnesyl diphosphate
mutant enzyme W279M, at pH 7.5 and 25°C
0.0019
(2E,6E)-farnesyl diphosphate
recombinant mutant W279M, pH 7.5, 25°C
0.0022
(2E,6E)-farnesyl diphosphate
recombinant mutant W279A, pH 7.5, 25°C
0.00223
(2E,6E)-farnesyl diphosphate
mutant enzyme W279A, at pH 7.5 and 25°C
0.0032
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 8.0 and 30°C
0.0032
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 7.5 and 25°C
0.00428
(2E,6E)-farnesyl diphosphate
mutant enzyme W279Y, at pH 7.5 and 25°C
0.0043
(2E,6E)-farnesyl diphosphate
recombinant mutant W279Y, pH 7.5, 25°C
0.0048
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C
0.008
(2E,6E)-farnesyl diphosphate
mutant enzyme W279Q, at pH 7.5 and 25°C
0.008
(2E,6E)-farnesyl diphosphate
recombinant mutant W279Q, pH 7.5, 25°C
0.0092
(2E,6E)-farnesyl diphosphate
recombinant mutant W279D, pH 7.5, 25°C
0.00924
(2E,6E)-farnesyl diphosphate
mutant enzyme W279D, at pH 7.5 and 25°C
0.00945
(2E,6E)-farnesyl diphosphate
mutant enzyme W279L, at pH 7.5 and 25°C
0.0095
(2E,6E)-farnesyl diphosphate
recombinant mutant W279L, pH 7.5, 25°C
0.0184
(2E,6E)-farnesyl diphosphate
pH and temperature not specified in the publication
0.0024
(2E,6Z)-farnesyl diphosphate
D451A mutant protein
0.0031
(2E,6Z)-farnesyl diphosphate
D452A mutant protein
0.0032
(2E,6Z)-farnesyl diphosphate
wild-type protein
0.043
(2E,6Z)-farnesyl diphosphate
D308A mutant protein
0.0017
2-trans,6-trans-farnesyl diphosphate
pH 7, 30°C, fusion protein composed of the pXC1-encoded protein and the histidine leader peptide derived from pET28
0.00605
2-trans,6-trans-farnesyl diphosphate
pH 7.5, 30ºC, recombinant CDN1-C1 enzyme
0.007
2-trans,6-trans-farnesyl diphosphate
-
isoenzyme CAD1-A, pH 8.7, 30°C
0.0106
2-trans,6-trans-farnesyl diphosphate
-
-
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0.00059 - 0.694
(2E,6E)-farnesyl diphosphate
0.01 - 0.043
(2E,6Z)-farnesyl diphosphate
0.033
2-trans,6-trans-farnesyl diphosphate
fusion protein composed of the pXC1-encoded protein and the histidine leader peptide derived from pET28, pH 7, 30°C
0.00059
(2E,6E)-farnesyl diphosphate
mutant enzyme W279E, at pH 7.5 and 25°C
0.00059
(2E,6E)-farnesyl diphosphate
recombinant mutant W279E, pH 7.5, 25°C
0.00067
(2E,6E)-farnesyl diphosphate
mutant enzyme W279D, at pH 7.5 and 25°C
0.00067
(2E,6E)-farnesyl diphosphate
recombinant mutant W279D, pH 7.5, 25°C
0.00073
(2E,6E)-farnesyl diphosphate
mutant enzyme W279Y, at pH 7.5 and 25°C
0.00073
(2E,6E)-farnesyl diphosphate
recombinant mutant W279Y, pH 7.5, 25°C
0.001
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 7.5 and 25°C
0.00109
(2E,6E)-farnesyl diphosphate
mutant enzyme W279M, at pH 7.5 and 25°C
0.0011
(2E,6E)-farnesyl diphosphate
recombinant mutant W279M, pH 7.5, 25°C
0.00127
(2E,6E)-farnesyl diphosphate
His-tagged recombinant enzyme, at pH 7.5 and 25°C
0.00127
(2E,6E)-farnesyl diphosphate
recombinant His6-tagged wild-type enzyme, pH 7.5, 25°C
0.003
(2E,6E)-farnesyl diphosphate
mutant enzyme W279Q, at pH 7.5 and 25°C
0.003
(2E,6E)-farnesyl diphosphate
recombinant mutant W279Q, pH 7.5, 25°C
0.0031
(2E,6E)-farnesyl diphosphate
recombinant mutant W279A, pH 7.5, 25°C
0.00312
(2E,6E)-farnesyl diphosphate
mutant enzyme W279A, at pH 7.5 and 25°C
0.0038
(2E,6E)-farnesyl diphosphate
mutant enzyme W279L, at pH 7.5 and 25°C
0.0038
(2E,6E)-farnesyl diphosphate
recombinant mutant W279L, pH 7.5, 25°C
0.01
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 8.0 and 30°C
0.04
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C
0.694
(2E,6E)-farnesyl diphosphate
pH and temperature not specified in the publication
0.01
(2E,6Z)-farnesyl diphosphate
wild-type protein
0.012
(2E,6Z)-farnesyl diphosphate
D308A mutant protein
0.014
(2E,6Z)-farnesyl diphosphate
D452A mutant protein
0.043
(2E,6Z)-farnesyl diphosphate
D451A mutant protein
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0.073 - 37.7
(2E,6E)-farnesyl diphosphate
0.073
(2E,6E)-farnesyl diphosphate
recombinant mutant W279D, pH 7.5, 25°C
0.17
(2E,6E)-farnesyl diphosphate
recombinant mutant W279Y, pH 7.5, 25°C
0.38
(2E,6E)-farnesyl diphosphate
recombinant mutant W279Q, pH 7.5, 25°C
0.4
(2E,6E)-farnesyl diphosphate
recombinant mutant W279L, pH 7.5, 25°C
0.41
(2E,6E)-farnesyl diphosphate
recombinant mutant W279E, pH 7.5, 25°C
0.58
(2E,6E)-farnesyl diphosphate
recombinant mutant W279M, pH 7.5, 25°C
0.7
(2E,6E)-farnesyl diphosphate
mutant enzyme W279D, at pH 7.5 and 25°C
1.41
(2E,6E)-farnesyl diphosphate
recombinant mutant W279A, pH 7.5, 25°C
1.7
(2E,6E)-farnesyl diphosphate
mutant enzyme W279Y, at pH 7.5 and 25°C
2.2
(2E,6E)-farnesyl diphosphate
recombinant His6-tagged wild-type enzyme, pH 7.5, 25°C
2.5
(2E,6E)-farnesyl diphosphate
mutant enzyme W279Q, at pH 7.5 and 25°C
3.1
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 8.0 and 30°C
4
(2E,6E)-farnesyl diphosphate
mutant enzyme W279L, at pH 7.5 and 25°C
4.1
(2E,6E)-farnesyl diphosphate
mutant enzyme W279E, at pH 7.5 and 25°C
5.7
(2E,6E)-farnesyl diphosphate
mutant enzyme W279M, at pH 7.5 and 25°C
14
(2E,6E)-farnesyl diphosphate
mutant enzyme W279A, at pH 7.5 and 25°C
21.7
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 7.5 and 25°C
31
(2E,6E)-farnesyl diphosphate
wild type enzyme, at pH 7.5 and 25°C
37.7
(2E,6E)-farnesyl diphosphate
pH and temperature not specified in the publication
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evolution
the CAD is encoded by a gene family, which is divided into two subfamilies CAD1-A and CAD1-C (Cdn1-C1, Cdn1-C14, Cdn1-A and Cdn1-C3), based on sequence similarities. The diploid genome of Gossypium arboreum contains about six members of CAD1- C and a single copy of CAD1-A
malfunction
if W279 in delta-cadinene synthase is replaced with various smaller amino acids, the ratio of alcohol versus hydrocarbon product is directly proportional to the van der Waals volume of the amino acid side chain. Mutant DCS-W279A is a catalytically highly efficient germacradien-4-ol synthase that produces predominantly germacradien-4-ol in addition to 11% delta-cadinene
metabolism
possible mechanism of sesquiterpene synthases from Piper nigrum. The reaction pathway is based on 1,10-ring closure pathway including enzyme PnCO/CDS
physiological function
enzyme DCS from Gossypium arboreum produces (+)-delta-cadinene in the first committed step of the biosynthetic pathway to the phytoalexin gossypol
physiological function
in cotton, (+)-delta-cadinene synthase (CAD) catalyses the cyclization of farnesyl diphosphate to (+)-delta-cadinene via a nerolidyl diphosphate intermediate and is the first step in the biosynthesis of gossypol and its precursor terpene aldehyde
physiological function
in cotton, (+)-delta-cadinene synthase (CAD) catalyses the cyclization of farnesyl diphosphate to (+)-delta-cadinene via a nerolidyl diphosphate intermediate and is the first step in the biosynthesis of gossypol and its precursor terpene aldehyde. Increased enzyme expression due to jasmonic acid treatment or plant growth-promoting rhizobacteria (PGPR) treatment leads to increased levels of gossypol in plants. Cotton pathogen Spodoptera exigua shows reduced larval feeding and development on PGPR-treated plants
physiological function
the enzyme distributes to systemic resistance in cotton against beet armyworm Spodoptera exigua
physiological function
the enzyme is involved in biosynthesis of beta-copaene and beta-cadinene (EC 4.2.3.13). In the unripe fruit, thirteen sesquiterpenes including beta-caryophyllene, delta-elemene, alpha-copaene, cubebene, alpha-humulene, delta-cadinol, and gamma- and delta-cadinenes are found. beta-Caryophyllene is the most abundant compound among the observed sesquiterpenes (65.8% of the total), followed by copaene (8.3%). During fruit ripening, the contents of the sesquiterpenes derived from germacrene D, such as cubebene, copaene, cubeol, and germacrene D-4?-ol, are progressively declined, most likely due to diminished total germacrene D synthase activity
additional information
catalytic mechanisms of (+)-delta-cadinene synthase (DCS) and germacradien-4-ol synthase (GdolS) catalysed conversions of (2E,6E)-farnesyl diphosphate to of (+)-delta-cadinene and germacradien-4-ol, analysis of the mechanism by which sesquiterpene synthases discriminate between deprotonation and reaction with a nucleophilic water molecule, molecular dynamics simulations, overview. Enzyme active site structure with bound Mg2+ ions
additional information
PnTPS2-transformed yeast cells accumulate delta-cadinol as a major product (91%) and smaller amounts of alpha-cadinene (2%) and delta-cadinene (7%). Recombinant expression of Piper nigrum germacrene D synthase (PnGDS) in yeast yields increased beta-cadinene and alpha-copaene contents
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D307A
aspartate-rich motif interacts with putative Mg2+
D308A
aspartate-rich motif interacts with putative Mg2+
D311A
aspartate-rich motif interacts with putative Mg2+
D451A
aspartate-rich motif interacts with putative Mg2+
D452A
aspartate-rich motif interacts with putative Mg2+
E455A
aspartate-rich motif interacts with putative Mg2+
L405H
-
mutation alters product selectivity from (+)-d-cadinene to germacrene D-4-ol (53%). Mutation improves the solubility of the enzyme
N403P
-
mutation significantly alters the product selectivity to germacrene D-4-ol (52%)
N403P/L405H
-
mutant maintains its specific activity and shows higher selectivity to germacrene D-4-ol in vivo (up to 93%)
additional information
if W279 in delta-cadinene synthase is replaced with various smaller amino acids, the ratio of alcohol versus hydrocarbon product is directly proportional to the van der Waals volume of the amino acid side chain
N403P/L405H
the double-mutant DCS converts farnesyl diphosphate into germacradien-4-ol (93%) and an additional unidentified cyclic sesquiterpene alcohol. The catalytic activity of DCS mutant N403P/L405H is severely compromised relative to that of the wild-type enzyme
N403P/L405H
the mutant enzyme converts (2E,6E)-farnesyl diphosphate into germacradien-4-ol (93%) and an additional unidentified cyclic sesquiterpene alcohol.However, the catalytic activity of the mutant is severely compromised relative to that of the wild type enzyme
W279A
site-directed mutagenesis, the mutant is a catalytically highly efficient germacradien-4-ol synthase that produces predominantly germacradien-4-ol in addition to 11% delta-cadinene
W279A
the mutant is a catalytically highly efficient germacradien-4-ol synthase that produces predominantly germacradien-4-ol (89%) in addition to 11% (+)-delta-cadinene
W279D
site-directed mutagenesis, the mutant shows altered substrate specificity and increased germacradien-4-ol synthase activity compared to the wild-type enzyme
W279D
the mutant produces 60% germacradien-4-ol and 40% (+)-delta-cadinene from (2E,6E)-farnesyl diphosphate
W279E
site-directed mutagenesis, the mutant shows altered substrate specificity and increased germacradien-4-ol synthase activity compared to the wild-type enzyme
W279E
the mutant produces 50% germacradien-4-ol and 50% (+)-delta-cadinene from (2E,6E)-farnesyl diphosphate
W279L
site-directed mutagenesis, the mutant shows altered substrate specificity and increased germacradien-4-ol synthase activity compared to the wild-type enzyme
W279L
the mutant produces 32% germacradien-4-ol and 68% (+)-delta-cadinene from (2E,6E)-farnesyl diphosphate
W279M
site-directed mutagenesis, the mutant shows altered substrate specificity and increased germacradien-4-ol synthase activity compared to the wild-type enzyme
W279M
the mutant produces 35% germacradien-4-ol and 65% (+)-delta-cadinene from (2E,6E)-farnesyl diphosphate
W279Q
site-directed mutagenesis, the mutant shows altered substrate specificity and increased germacradien-4-ol synthase activity compared to the wild-type enzyme
W279Q
the mutant produces 40% germacradien-4-ol and 60% (+)-delta-cadinene from (2E,6E)-farnesyl diphosphate
W279Y
site-directed mutagenesis, the mutant shows altered substrate specificity and increased germacradien-4-ol synthase activity compared to the wild-type enzyme
W279Y
the mutant produces 17% germacradien-4-ol and 83% (+)-delta-cadinene from (2E,6E)-farnesyl diphosphate
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Gossypium hirsutum
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Gossypium hirsutum
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Gossypium barbadense
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