Application | Comment | Organism |
---|---|---|
drug development | discovery and development of carbonic anhydrase inhibitors is crucial for their clinical use as antiepileptic, diurectic, and antiglaucoma agents | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | carbohydrazones as another class of carbonic anhydrase inhibitors, synthesis, kinetics, and ligand docking studies, overview. Single crystal X-ray diffraction, structural coordinates of bovine carbonic anhydrase (PDB ID 1V9E) is used for docking of carbohydrazone compounds, three-dimensional structure analysis. No inhibition by N'',N'''-bis[(E)-(4-chlorophenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2-fluorophenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-phenylmethylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2-hydroxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(3-hydroxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(4-hydroxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2,3-dihydroxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2,5-dihydroxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(5-bromo-2-hydroxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2,4,6-trihydroxyphenyl)methylidene]carbonicdihydrazide, N'',N'''-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2-methoxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(3-methoxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(4-methoxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2-hydroxy-5-methoxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]carbonic dihydrazide, N'',N'''-bis[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]carbonic dihydrazide, and N'',N'''-bis[(E)-(3,4-dimethoxyphenyl)methylidene]carbonic dihydrazide | Bos taurus | |
N'',N'''-Bis[(E)-(2,4-dichlorophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(2,6-dichlorophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(2-bromophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(2-chloro-5-nitrophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(2-chlorophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(2-nitrophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(4-bromophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(4-fluorophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
N'',N'''-bis[(E)-(4-nitrophenyl)methylidene]carbonic dihydrazide | - |
Bos taurus | |
zonisamide | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required, metalloenzyme | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | Bos taurus | - |
CO2 + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P00921 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | purified bovine erythrocyte CA-II | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2CO3 | - |
Bos taurus | CO2 + H2O | - |
r | |
additional information | enzyme activity assay with 4-nitrophenyl acetate as substrate using the enzyme's esterase activity | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CA-II | - |
Bos taurus |
carbonic anhydrase II | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00186 | - |
pH 7.4, 25°C | Bos taurus | zonisamide |