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Literature summary for 4.2.1.1 extracted from

  • Briganti, F.; Tilli, S.; Mincione, G.; Mincione, F.; Menabuoni, L.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Metal complexes of 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide with topical intraocular pressure lowering properties: The influence of metal ions upon the pharmacological activity (2000), J. Enzyme Inhib., 15, 185-200.
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
CA I and CA II cDNA expressed in Escherichia coli BL21 (DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
 Bos taurus
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
acetazolamide
-
 Bos taurus
acetazolamide
-
 Homo sapiens
benzolamide
-
 Bos taurus
benzolamide
-
 Homo sapiens
chlorazolamide
-
 Bos taurus
chlorazolamide
-
 Homo sapiens
dorzolamide
-
 Bos taurus
dorzolamide
-
 Homo sapiens
ethoxzolamide
-
 Bos taurus
ethoxzolamide
-
 Homo sapiens
methazolamide
-
 Bos taurus
methazolamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Homo sapiens
Zn2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r
H2CO3 Bos taurus
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Homo sapiens CO2 + H2O
-
 r
H2CO3
-
 Bos taurus CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
bCA IV
-
 Homo sapiens
bCA IV
-
 Bos taurus
CA
-
 Homo sapiens
CA
-
 Bos taurus
CA I
-
 Homo sapiens
CA II
-
 Homo sapiens
CA IV
-
 Homo sapiens
carbonic anhydrase
-
 Homo sapiens
carbonic anhydrase
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000003
-
 chlorazolamide pH 7.4, 25°C, hCA II Homo sapiens
0.000008
-
 ethoxzolamide pH 7.4, 25°C, hCA II Homo sapiens
0.000009
-
 dorzolamide pH 7.4, 25°C, hCA II Homo sapiens
0.000009
-
 benzolamide pH 7.4, 25°C, hCA II Homo sapiens
0.000012
-
 benzolamide pH 7.4, 25°C, bCA IV Bos taurus
0.000012
-
 acetazolamide pH 7.4, 25°C, hCA II Homo sapiens
0.000013
-
 ethoxzolamide pH 7.4, 25°C, bCA IV Bos taurus
0.000014
-
 methazolamide pH 7.4, 25°C, hCA II Homo sapiens
0.000015
-
 chlorazolamide pH 7.4, 25°C, bCA IV Bos taurus
0.000015
-
 chlorazolamide pH 7.4, 25°C, hCA I Homo sapiens
0.000018
-
 benzolamide pH 7.4, 25°C, hCA I Homo sapiens
0.000025
-
 ethoxzolamide pH 7.4, 25°C, hCA I Homo sapiens
0.000043
-
 dorzolamide pH 7.4, 25°C, bCA IV Bos taurus
0.00022
-
 acetazolamide pH 7.4, 25°C, bCA IV Bos taurus
0.00024
-
 methazolamide pH 7.4, 25°C, bCA IV Bos taurus
0.00078
-
 methazolamide pH 7.4, 25°C, hCA I Homo sapiens
0.0009
-
 acetazolamide pH 7.4, 25°C, hCA I Homo sapiens
0.05
-
 dorzolamide pH 7.4, 25°C, hCA I Homo sapiens