Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.3.24 extracted from

  • Hersh, L.B.
    Malyl coenzyme A lyase. Mechanism of action as deduced by kinetic analysis (1974), J. Biol. Chem., 249, 5208-5212.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl-CoA in direction of malyl-CoA cleavage: noncompetitive with respect to malyl-CoA Pseudomonas sp.
glycolate in direction of malyl-CoA synthesis: competitive with respect to glyoxylate and noncompetitive with respect to acetyl-CoA.In direction of malyl-CoA cleavage: competitive with respect to malyl-CoA Pseudomonas sp.
oxalate in direction of malyl-CoA synthesis: competitive with respect to glyoxylate and noncompetitive with respect to acetyl-CoA. In direction of malyl-CoA cleavage: competitive with respect to malyl-CoA Pseudomonas sp.
oxylate in direction of malyl-CoA cleavage: competitive with respect to malyl-CoA Pseudomonas sp.
propionyl-CoA in direction of malyl-CoA synthesis: uncompetitive with respect to glyoxylate and competitive with respect to acetyl-CoA. In direction of malyl-CoA cleavage: noncompetitive with respect to malyl-CoA Pseudomonas sp.

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
Shaw strain MA
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas sp.

Reaction

Reaction Comment Organism Reaction ID
(S)-malyl-CoA = acetyl-CoA + glyoxylate in the reverse direction ordered sequential mechanism with glyoxylate binding prior to acetyl-CoA Pseudomonas sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Pseudomonas sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-3-carboxy-3-hydroxypropanoyl-CoA
-
Pseudomonas sp. acetyl-CoA + glyoxylate
-
r
acetyl-CoA + glyoxylate
-
Pseudomonas sp. (3S)-3-carboxy-3-hydroxypropanoyl-CoA
-
r