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Literature summary for 3.9.1.3 extracted from

  • Hindupur, S.K.; Colombi, M.; Fuhs, S.R.; Matter, M.S.; Guri, Y.; Adam, K.; Cornu, M.; Piscuoglio, S.; Ng, C.K.Y.; Betz, C.; Liko, D.; Quagliata, L.; Moes, S.; Jenoe, P.; Terracciano, L.M.; Heim, M.H.; Hunter, T.; Hall, M.N.
    The protein histidine phosphatase LHPP is a tumour suppressor (2018), Nature, 555, 678-682 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.9.1.3

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H008 cf. EC 3.6.1.1
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Mus musculus Q9D7I5 cf. EC 3.6.1.1
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Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell in patients with hepatocellular carcinoma, low expression of LHPP correlated with increased tumour severity and reduced overall survival Homo sapiens
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liver hepatic expression of LHPP in the hepatocellular carcinoma mouse model reduces tumour burden and prevents the loss of liver function Mus musculus
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Synonyms

Synonyms Comment Organism
LHPP
-
 Mus musculus
LHPP
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus downregulated specifically in tumours down
Homo sapiens downregulated specifically in tumours down

General Information

General Information Comment Organism
metabolism LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic Mus musculus
metabolism LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic Homo sapiens