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Information on EC - phosphohistidine phosphatase

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This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- and tele-nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) . The substrate specificity depends on the amino acid sequence or structural context of the phosphohistidine in a phosphoprotein. The enzyme is also active on free phosphoramidate [1,4] and peptide-bound phospholysine .
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
phpt1, php14, protein histidine phosphatase, phpt-1, 14-kda phosphohistidine phosphatase, phospho-histidine phosphatase, phosphohistidine phosphatase 1, protein histidine phosphatase 1, 14 kda phosphohistidine phosphatase, histidine protein phosphatase, more
a [protein]-N-phospho-L-histidine + H2O = a [protein]-L-histidine + phosphate
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