Literature summary for 3.9.1.3 extracted from

Srivastava, S.; Zhdanova, O.; Di, L.; Li, Z.; Albaqumi, M.; Wulff, H.; Skolnik, E.Y.
Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1 (2008), Proc. Natl. Acad. Sci. USA, 105, 14442-14446.

Search for more literature for 3.9.1.3

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in CHO cells	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
14000	-	x * 14000, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[KCa3.1 channel protein]-N-phospho-L-histidine + H2O	Homo sapiens	the enzyme directly binds and inhibits KCa3.1 by dephosphorylating histidine 358	[KCa3.1 channel protein]-L-histidine + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
culture condition:CD4+ cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[KCa3.1 channel protein]-N-phospho-L-histidine + H2O	the enzyme directly binds and inhibits KCa3.1 by dephosphorylating histidine 358	Homo sapiens	[KCa3.1 channel protein]-L-histidine + phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 14000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
PHPT-1	-	Homo sapiens
protein histidine phosphatase 1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	decreased expression of PHPT-1 in human CD4 T cells results in an increase in KCa3.1 channel activity and increases Ca2+ influx and proliferation after T cell receptor activation	Homo sapiens
physiological function	the endogenous enzyme negatively regulates CD4 T cells	Homo sapiens

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Release 2023.1 (January 2023)