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Literature summary for 3.9.1.3 extracted from

  • Matthews, H.R.; MacKintosh, C.
    Protein histidine phosphatase activity in rat liver and spinach leaves (1995), FEBS Lett., 364, 51-54.
    View publication on PubMed
Search for more literature for 3.9.1.3

Inhibitors

Inhibitors Comment Organism Structure
Inhibitor-2 isoform PP1, but not PP2A, is inhibited by inhibitor-2 Rattus norvegicus
Inhibitor-2 isoform PP1, but not PP2A, is inhibited by inhibitor-2 Spinacia oleracea
additional information isoform PP1 is unaffected by 3 nM okadaic acid Rattus norvegicus
additional information isoform PP1 is unaffected by 3 nM okadaic acid Spinacia oleracea
okadaic acid isoform PP1 is inhibited by 0.001 mM okadaic acid and isoform PP2A by 3 nM okadaic acid Rattus norvegicus
okadaic acid isoform PP1 is inhibited by 0.001 mM okadaic acid and isoform PP2A by 3 nM okadaic acid Spinacia oleracea

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
cytosol
-
 Spinacia oleracea 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the enzyme is divalent ion-independent Rattus norvegicus
additional information the enzyme is divalent ion-independent Spinacia oleracea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H4]-N-phospho-L-histidine + H2O Rattus norvegicus
-
 [histone H4]-L-histidine + phosphate
-
 ?
[histone H4]-N-phospho-L-histidine + H2O Spinacia oleracea
-
 [histone H4]-L-histidine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Spinacia oleracea
-
-
-

Purification (Commentary)

Purification (Comment) Organism
MonoQ column chromatography Rattus norvegicus
MonoQ column chromatography Spinacia oleracea

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Spinacia oleracea
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H4]-N-phospho-L-histidine + H2O
-
 Rattus norvegicus [histone H4]-L-histidine + phosphate
-
 ?
[histone H4]-N-phospho-L-histidine + H2O
-
 Spinacia oleracea [histone H4]-L-histidine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP1 isoform Rattus norvegicus
PP1 isoform Spinacia oleracea
PP2A isoform Rattus norvegicus
PP2A isoform Spinacia oleracea
protein histidine phosphatase
-
 Rattus norvegicus
protein histidine phosphatase
-
 Spinacia oleracea