Protein Variants | Comment | Organism |
---|---|---|
N146Q | decreased secretion and von Willebrand factor cleaving activity | Homo sapiens |
N552Q | decreased secretion | Homo sapiens |
N828Q | decreased secretion and von Willebrand factor cleaving activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q76LX8 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycosylation is necessary for efficient secretion of ADAMTS13, while conversion of the N-glycans from oligomannose to complex type in the Golgi complex enhances the proteolytic activity of the protease toward von Willebrand factor multimers. After its secretion, ADAMTS13 does not require N-glycans for its von Willebrand factor cleaving activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
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