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Literature summary for 3.4.24.86 extracted from

  • Udechukwu, M.; Tsopmo, A.; Mawhinney, H.; He, R.; Kienesberger, P.; Udenigwe, C.
    Inhibition of ADAM17/TACE activity by zinc-chelating rye secalin-derived tripeptides and analogues (2017), RSC Adv., 7, 26361-26369 .
No PubMed abstract available
Search for more literature for 3.4.24.86

Inhibitors

Inhibitors Comment Organism Structure
Cys-Gln-Val tripeptide Cys-Gln-Val shows about 50%, 30% and 25% residual activity at 0.0005, 0.00005 and 0.000005 mM, respectively Homo sapiens
Gln-Cys-Ala tripeptide Gln-Cys-Ala shows about 35%, 20% and 22% residual activity at 0.0005, 0.00005 and 0.000005 mM, respectively Homo sapiens
Gln-Cys-Val tripeptide Gln-Cys-Val shows about 45%, 28% and 10% residual activity at 0.0005, 0.00005 and 0.000005 mM, respectively Homo sapiens
Gln-Val-Cys tripeptide Gln-Val-Cys shows about 59%, 40% and 8% residual activity at 0.0005, 0.00005 and 0.000005 mM, respectively Homo sapiens
additional information the enzyme is not inhibited by 0.005 mM glutathione Homo sapiens
TAPI-1 TAPI-1 inhibits 19% and 45% of enzyme activity at 0.0001 and 0.0001 mM, respectively Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mca-PLAQAVDpa-RSSSR-NH2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase 17
-
 Homo sapiens
ADAM17
-
 Homo sapiens
TACE
-
 Homo sapiens
TNF-alpha converting enzyme
-
 Homo sapiens
tumour necrosis factor-alpha converting enzyme
-
 Homo sapiens