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Information on EC 3.4.24.86 - ADAM 17 endopeptidase

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.86 ADAM 17 endopeptidase
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
adam17, adam-17, tnf-alpha converting enzyme, tace/adam17, tumor necrosis factor-alpha converting enzyme, tumor necrosis factor-alpha-converting enzyme, a disintegrin and metalloprotease 17, metalloproteinase adam17, tumor necrosis factor alpha-converting enzyme, tumor necrosis factor alpha converting enzyme, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains
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proTNF-alpha + H2O = soluble TNF-alpha. Cleavage of the precursor of tumor necrosis factor proTNFalpha to the mature tumor necrosis factor TNF-alpha, Swiss-Prot Acesssion Numbers: P78536(human), Q77636(pig), Q9Z1K9(rat), Q9Z0F8(mouse), Q923X3(chinese hamster). In peptidase family M12. In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNFa, which induces inflammation.
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