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Literature summary for 3.4.24.86 extracted from

  • Qian, M.; Shen, X.; Wang, H.
    The distinct role of ADAM17 in APP proteolysis and microglial activation related to Alzheimer's disease (2016), Cell. Mol. Neurobiol., 36, 471-482 .
    View publication on PubMed
Search for more literature for 3.4.24.86

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amphiregulin + H2O Homo sapiens
-
 ?
-
 ?
amyloid precursor protein + H2O Homo sapiens
-
 soluble amyloid precursor protein alpha fragment + C83
-
 ?
betacellulin + H2O Homo sapiens
-
 ?
-
 ?
CD44 + H2O Homo sapiens
-
 ?
-
 ?
CX3CL1 + H2O Homo sapiens
-
 ?
-
 ?
CXCR2 + H2O Homo sapiens
-
 ?
-
 ?
epiregulin + H2O Homo sapiens
-
 ?
-
 ?
HB-EGF + H2O Homo sapiens
-
 ?
-
 ?
interleukin 1 receptor + H2O Homo sapiens
-
 ?
-
 ?
interleukin 1alpha/beta + H2O Homo sapiens
-
 ?
-
 ?
interleukin 6 + H2O Homo sapiens
-
 ?
-
 ?
interleukin 6 receptor + H2O Homo sapiens
-
 ?
-
 ?
L-selectin + H2O Homo sapiens
-
 ?
-
 ?
N-cadherin + H2O Homo sapiens
-
 ?
-
 ?
NCAM + H2O Homo sapiens
-
 ?
-
 ?
TGFalpha + H2O Homo sapiens
-
 ?
-
 ?
TNFalpha + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78536
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amphiregulin + H2O
-
 Homo sapiens ?
-
 ?
amyloid precursor protein + H2O
-
 Homo sapiens soluble amyloid precursor protein alpha fragment + C83
-
 ?
betacellulin + H2O
-
 Homo sapiens ?
-
 ?
CD44 + H2O
-
 Homo sapiens ?
-
 ?
CX3CL1 + H2O
-
 Homo sapiens ?
-
 ?
CXCR2 + H2O
-
 Homo sapiens ?
-
 ?
epiregulin + H2O
-
 Homo sapiens ?
-
 ?
HB-EGF + H2O
-
 Homo sapiens ?
-
 ?
interleukin 1 receptor + H2O
-
 Homo sapiens ?
-
 ?
interleukin 1alpha/beta + H2O
-
 Homo sapiens ?
-
 ?
interleukin 6 + H2O
-
 Homo sapiens ?
-
 ?
interleukin 6 receptor + H2O
-
 Homo sapiens ?
-
 ?
L-selectin + H2O
-
 Homo sapiens ?
-
 ?
N-cadherin + H2O
-
 Homo sapiens ?
-
 ?
NCAM + H2O
-
 Homo sapiens ?
-
 ?
TGFalpha + H2O
-
 Homo sapiens ?
-
 ?
TNFalpha + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease 17
-
 Homo sapiens
ADAM17
-
 Homo sapiens
TACE
-
 Homo sapiens
TNFalpha converting enzyme
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function from one hand, ADAM17 is neuroprotective, since it cleaves amyloid precursor protein as alpha-secretase to inhibit Abeta generation. From the other hand, ADAM17 is neurotoxic, since it is also the sheddase of many pro-inflammatory factors Homo sapiens