Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.86 extracted from

  • Peng, M.; Guo, S.; Yin, N.; Xue, J.; Shen, L.; Zhao, Q.; Zhang, W.
    Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17 (2010), Immunology, 130, 83-91.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.86

Inhibitors

Inhibitors Comment Organism Structure
EDTA 1 mM, treatment of cells dramatically inhibits shedding of shedding of FcalphaR, i.e. Fc receptor for immunoglobulin A Homo sapiens
EGTA 1 mM, treatment of cells dramatically inhibits shedding of shedding of FcalphaR, i.e. Fc receptor for immunoglobulin A Homo sapiens
GM6001 broad-spectrum metalloproteinase inhibitor, treatment of cells dramatically inhibits shedding of shedding of FcalphaR, i.e. Fc receptor for immunoglobulin A Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FcalphaR + H2O i.e. Fc receptor for immunoglobulin A Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function knockdown of both endogenous ADAM10 and endogenous ADAM17 by siRNA inhibits FcalphaR, i.e. Fc receptor for immunoglobulin A, shedding Homo sapiens