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Literature summary for 3.4.24.86 extracted from

  • Parkin, E.T.; Trew, A.; Christie, G.; Faller, A.; Mayer, R.; Turner, A.J.; Hooper, N.M.
    Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha (2002), Biochemistry, 41, 4972-4981.
    View publication on PubMed
Search for more literature for 3.4.24.86

Activating Compound

Activating Compound Comment Organism Structure
phorbol ester
-
 Mus musculus
phorbol ester
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Hydroxamate
-
 Chlorocebus aethiops
Hydroxamate
-
 Homo sapiens
Hydroxamate
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Chlorocebus aethiops
-
 african green monkey, COS-7, an SV40 transformed kidney cell line
-
Homo sapiens
-
 SH-SY5Y
-
Homo sapiens
-
 human monocytic cell line THP-1
-
Homo sapiens
-
 HEK293 cells
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Mus musculus
-
blood
-
 Homo sapiens
-
embryo
-
 Mus musculus
-
embryo
-
 Homo sapiens
-
fibroblast
-
 Mus musculus
-
fibroblast
-
 Homo sapiens
-
kidney
-
 Mus musculus
-
kidney
-
 Homo sapiens
-
kidney
-
 Chlorocebus aethiops
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein + H2O
-
 Mus musculus ?
-
 ?
beta-amyloid precursor protein + H2O Alzheimer amyloid precursor protein Homo sapiens ?
-
 ?
proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?
transforming growth factor alpha + H2O
-
 Chlorocebus aethiops ?
-
 ?