Literature summary for 3.4.24.65 extracted from

Bauters, D.; Van Hul, M.; Lijnen, H.
Macrophage elastase (MMP-12) in expanding murine adipose tissue (2013), Biochim. Biophys. Acta, 1830, 2954-2959.

Search for more literature for 3.4.24.65

Application

Application	Comment	Organism
medicine	in MMP-12 deficient mice, deficiency has no significant effect on total body weight or on subcutaneous or gonadal adipose tissue mass. Adipocyte and blood vessel size and density in subcutaneous and gonadal adipose tissues of obese mice are also comparable in MMP-12 deficient and control mice. Macrophage infiltration in subcutaneous and gonadal adipose tissues is not affected by MMP-12 deficiency, but the amount of crown-like structures is significantly lower. MMP-12 deficiency does not affect elastin content in the extracellular matrix of subcutaneous or gonadal adipose tissue	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P34960	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

General Information

General Information	Comment	Organism
physiological function	in MMP-12 deficient mice, deficiency has no significant effect on total body weight or on subcutaneous or gonadal adipose tissue mass. Adipocyte and blood vessel size and density in subcutaneous and gonadal adipose tissues of obese mice are also comparable in MMP-12 deficient and control mice. Macrophage infiltration in subcutaneous and gonadal adipose tissues is not affected by MMP-12 deficiency, but the amount of crown-like structures is significantly lower. MMP-12 deficiency does not affect elastin content in the extracellular matrix of subcutaneous or gonadal adipose tissue	Mus musculus

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Release 2023.1 (January 2023)