Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MMP-12 is upregulated after the induction of asthmatic reaction | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
pharmacology | MMP-12 might be a target for the therapy against allergic bronchial asthma | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 54000, inactive proenzyme, x * 45000, intermediate enzyme | Rattus norvegicus |
54000 | - |
x * 54000, inactive proenzyme, x * 45000, intermediate enzyme | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is involved in the development of chronic obstructive pulmonary disease and airway inflammation and is associated with allergic bronchial asthma, phenotype, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | airway epithelia | Rattus norvegicus | - |
macrophage | alveolar macrophages | Rattus norvegicus | - |
additional information | immunohistochemical expression analysis | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative enzyme expression analysis by RT-PCR, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-casein + H2O | - |
Rattus norvegicus | ? | - |
? | |
additional information | the enzyme is involved in the development of chronic obstructive pulmonary disease and airway inflammation and is associated with allergic bronchial asthma, phenotype, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 54000, inactive proenzyme, x * 45000, intermediate enzyme | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-12 | - |
Rattus norvegicus |
MMP-12 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Rattus norvegicus |