Protein Variants | Comment | Organism |
---|---|---|
additional information | BACE1-null mice instrumental in validating roles of BACE1 in regulation of myelination | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P56818 | BACE1-null and wild-type mice at the ages of 2 and 5 months | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
genetic deletion of BACE1 causes hypomyelination, elevated pain sensitivity and reduced grip strength shown in BACE1-null mice, neuregulin-1 expression increased and cleavage products and phosphorylated AKT protein kinase shown to be decreased in BACE1-null mice, neuregulin-1 cleavage by BACE1 shown, processed neuregulin-1 regulates myelination by means of phosphorylation of AKT protein kinase in myelin-forming cells | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | BACE1 function in regulation of myelination and myelin sheath thickness in the central and peripheral nerves determined, abolishment of BACE1 shown to be associated with altered neurological behaviors such as elevated pain sensitivity and reduced grip strength, altered neuregulin-AKT kinase signalling pathway in BACE1-null mice shown | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Mus musculus |
beta-secretase | - |
Mus musculus |