Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu | BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Rattus norvegicus | first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Rattus norvegicus |