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Literature summary for 3.4.23.45 extracted from

  • Lahiri, D.K.; Maloney, B.; Ge, Y.W.
    Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells (2006), J. Mol. Neurosci., 29, 65-80.
    View publication on PubMed
Search for more literature for 3.4.23.45

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence analysis, expression analysis, sequence comparison to BACE1, functional expression in primary rat cortical cell cultures Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein APP + H2O Homo sapiens
-
 beta-amyloid protein + beta-amyloid precursor protein pre-peptide
-
 ?
additional information Homo sapiens the enzyme is involved in Alzheimer's disease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information tissue-type specific expression Homo sapiens
-
neuronal cell transcription control at two sites, tissue-specific expression, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein APP + H2O
-
 Homo sapiens beta-amyloid protein + beta-amyloid precursor protein pre-peptide
-
 ?
additional information the enzyme is involved in Alzheimer's disease Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More amino acid sequence and domain structure, comparison to BACE1 Homo sapiens

Synonyms

Synonyms Comment Organism
BACE2
-
 Homo sapiens