Dabcyl-KTSAVLQSGFRKME-EDANS-amide + H2O
717101
SARS coronavirus
Dabcyl-KTSAVLQ + SGFRKME-EDANS-amide
?
additional information
no activity towards SWTSAVKQSGFRKWA, SWTSAVRQSGFRKWA, SWTSAVEQSGFRKWA, and SWTSAVDQSGFRKWA
717101
SARS coronavirus
?
additional information
the substrate specificity of the enzyme requires glutamine in the P1 position and a large hydrophobic residue in the P2 position
717101
SARS coronavirus
?
SWTSAVAQSGFRKWA + H2O
less than 10% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVAQ + SGFRKWA
?
SWTSAVCQSGFRKWA + H2O
less than 1% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVCQ + SGFRKWA
?
SWTSAVFQSGFRKWA + H2O
about 70% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVFQ + SGFRKWA
?
SWTSAVHQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVHQ + SGFRKWA
?
SWTSAVIQSGFRKWA + H2O
about 45% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVIQ + SGFRKWA
?
SWTSAVLQSGFRKWA + H2O
100% activity
717101
SARS coronavirus
SWTSAVLQ + SGFRKWA
?
SWTSAVMQSGFRKWA + H2O
about 58% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVMQ + SGFRKWA
?
SWTSAVNQSGFRKWA + H2O
less than 1% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVNQ + SGFRKWA
?
SWTSAVPQSGFRKWA + H2O
about 10% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVPQ + SGFRKWA
?
SWTSAVQQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVQQ + SGFRKWA
?
SWTSAVSQSGFRKWA + H2O
less than 1% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVSQ + SGFRKWA
?
SWTSAVTQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVTQ + SGFRKWA
?
SWTSAVVQSGFRKWA + H2O
about 55% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVVQ + SGFRKWA
?
SWTSAVWQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVWQ + SGFRKWA
?
SWTSAVYQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVYQ + SGFRKWA
?
Dabcyl-KTSAVLQSGFRKME-EDANS-amide + H2O
717101
SARS coronavirus
Dabcyl-KTSAVLQ + SGFRKME-EDANS-amide
?
additional information
no activity towards SWTSAVKQSGFRKWA, SWTSAVRQSGFRKWA, SWTSAVEQSGFRKWA, and SWTSAVDQSGFRKWA
717101
SARS coronavirus
?
additional information
the substrate specificity of the enzyme requires glutamine in the P1 position and a large hydrophobic residue in the P2 position
717101
SARS coronavirus
?
SWTSAVAQSGFRKWA + H2O
less than 10% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVAQ + SGFRKWA
?
SWTSAVCQSGFRKWA + H2O
less than 1% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVCQ + SGFRKWA
?
SWTSAVFQSGFRKWA + H2O
about 70% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVFQ + SGFRKWA
?
SWTSAVHQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVHQ + SGFRKWA
?
SWTSAVIQSGFRKWA + H2O
about 45% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVIQ + SGFRKWA
?
SWTSAVLQSGFRKWA + H2O
100% activity
717101
SARS coronavirus
SWTSAVLQ + SGFRKWA
?
SWTSAVMQSGFRKWA + H2O
about 58% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVMQ + SGFRKWA
?
SWTSAVNQSGFRKWA + H2O
less than 1% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVNQ + SGFRKWA
?
SWTSAVPQSGFRKWA + H2O
about 10% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVPQ + SGFRKWA
?
SWTSAVQQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVQQ + SGFRKWA
?
SWTSAVSQSGFRKWA + H2O
less than 1% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVSQ + SGFRKWA
?
SWTSAVTQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVTQ + SGFRKWA
?
SWTSAVVQSGFRKWA + H2O
about 55% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVVQ + SGFRKWA
?
SWTSAVWQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVWQ + SGFRKWA
?
SWTSAVYQSGFRKWA + H2O
less than 5% activity compared to SWTSAVLQSGFRKWA
717101
SARS coronavirus
SWTSAVYQ + SGFRKWA
?
752729
Krichel
Processing of the SARS-CoV pp ...
SARS coronavirus
Biochem. J.
477
1009-1019
2020
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
752975
Yoshizawa
Evaluation of an octahydroiso ...
SARS coronavirus
Bioorg. Med. Chem.
28
115273
2020
-
-
-
-
-
-
8
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
7
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
753268
Morse
Learning from the Past Possib ...
SARS coronavirus
ChemBioChem
21
730-738
2020
-
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
753527
Chen
Prediction of the SARS-CoV-2 ...
Severe acute respiratory syndrome coronavirus 2
F1000Res.
9
129
2020
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
754293
Jo
Inhibition of SARS-CoV 3CL pr ...
SARS coronavirus
J. Enzyme Inhib. Med. Chem.
35
145-151
2020
-
-
1
-
-
-
3
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
3
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
754405
Dong
A guideline for homology mode ...
Severe acute respiratory syndrome coronavirus 2
J. Med. Virol.
FEHLT
0000
2020
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
754752
Ton
Rapid identification of poten ...
Severe acute respiratory syndrome coronavirus 2
Mol. Inform.
FEHLT
0000
2020
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
755546
Zhang
Crystal structure of SARS-CoV ...
SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Science
FEHLT
0000
2020
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
752974
Ohnishi
Evaluation of a non-prime sit ...
SARS coronavirus
Bioorg. Med. Chem.
27
425-435
2019
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
753344
Rahman
Lead molecule prediction and ...
Middle East respiratory syndrome-related coronavirus
Curr. Comput. Aided Drug Des.
15
82-88
2019
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
753538
Zhou
Identification of novel prote ...
porcine epidemic diarrhea virus
FASEB J.
33
14575-14587
2019
-
-
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
755284
Lim
Structurally- and dynamically ...
SARS coronavirus
Prog. Biophys. Mol. Biol.
143
52-66
2019
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
755639
Perera
Characterization of amino aci ...
feline coronavirus
Vet. Microbiol.
237
108398
2019
-
-
-
-
6
-
2
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
755651
Kanitz
Structural basis for catalysi ...
Alphamesonivirus 1
Virology
533
21-33
2019
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752992
Konno
Synthesis and evaluation of p ...
SARS coronavirus
Bioorg. Med. Chem. Lett.
27
2746-2751
2017
-
-
-
-
1
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
753488
Wang
Discovery of unsymmetrical ar ...
SARS coronavirus
Eur. J. Med. Chem.
137
450-461
2017
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
753022
Teruya
Structural basis for the deve ...
SARS coronavirus
Biopolymers
106
391-403
2016
-
-
1
1
1
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
1
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
755253
Muramatsu
SARS-CoV 3CL protease cleaves ...
SARS coronavirus
Proc. Natl. Acad. Sci. USA
113
12997-13002
2016
-
-
-
1
1
-
3
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
1
1
-
-
3
3
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
755419
Li
Conformational flexibility of ...
SARS coronavirus
Sci. Rep.
6
20918
2016
-
-
1
-
2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
752951
Shimamoto
Fused-ring structure of decah ...
SARS coronavirus
Bioorg. Med. Chem.
23
876-890
2015
-
-
-
1
-
-
12
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
1
-
-
11
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731320
Paasche
Evidence for substrate binding ...
SARS coronavirus
Biochemistry
53
5930-5946
2014
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
731060
Wu
Mechanism for controlling the ...
SARS coronavirus
Acta Crystallogr. Sect. D
69
747-755
2013
-
1
1
1
1
-
-
-
1
-
-
-
-
2
-
-
1
-
-
-
-
-
3
2
7
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
731443
Turlington
Discovery of N-(benzo[1,2,3]tr ...
SARS coronavirus
Bioorg. Med. Chem. Lett.
23
6172-6177
2013
-
-
-
1
-
-
44
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
31
-
-
-
-
1
-
-
31
44
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731748
Thanigaimalai
Design, synthesis, and biologi ...
SARS coronavirus
Eur. J. Med. Chem.
65
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1
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Synthesis, docking studies, an ...
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Mutation of Asn28 disrupts the ...
SARS coronavirus
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Chuck
Profiling of substrate specifi ...
SARS coronavirus
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Phakthanakanok
A computational analysis of SA ...
SARS coronavirus
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Individual and common inhibito ...
SARS coronavirus
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SARS coronavirus
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Regnier
New developments for the desig ...
SARS coronavirus
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2009
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15
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707798
Luo
Anti-SARS coronavirus 3C-like ...
SARS coronavirus
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1
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1
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1
2
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1
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Kuo
Engineering a novel endopeptid ...
SARS coronavirus
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16
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710675
Hu
Two adjacent mutations on the ...
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2009
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2
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-
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1
-
1
2
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-
-
-
-
-
-
-
-
-
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1
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1
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1
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678335
Solowiej
Steady-state and pre-steady-st ...
SARS coronavirus
Biochemistry
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2008
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5
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1
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5
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-
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-
-
-
-
-
-
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5
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-
-
-
-
-
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5
-
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Niu
Molecular docking identifies t ...
SARS coronavirus
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12
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12
13
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-
-
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-
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Mutation of Gly-11 on the dime ...
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1
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1
1
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1
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Correlation between dissociati ...
SARS coronavirus
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1
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12
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15
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1
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1
2
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Aryl methylene ketones and flu ...
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Mukherjee
Structure-based virtual screen ...
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2008
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2
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1
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2
2
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Shao
Design, synthesis, and evaluat ...
SARS coronavirus
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2008
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7
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Akaji
Evaluation of peptide-aldehyde ...
SARS coronavirus
Bioorg. Med. Chem.
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2008
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1
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Ghosh
Design, synthesis and antivira ...
SARS coronavirus
Bioorg. Med. Chem. Lett.
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2008
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1
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-
-
-
-
10
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-
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-
-
10
10
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-
-
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691735
Bacha
Development of broad-spectrum ...
SARS coronavirus
Chem. Biol. Drug Des.
72
34-49
2008
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-
-
1
-
-
5
-
-
-
-
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4
-
-
1
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-
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1
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-
-
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5
-
-
-
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1
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5
5
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-
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-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
691768
Yang
Design and synthesis of cinans ...
SARS coronavirus
Chem. Pharm. Bull.
56
1400-1405
2008
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-
-
-
-
-
9
-
-
-
-
-
-
3
-
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-
-
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1
-
-
-
-
-
-
-
-
-
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-
-
9
-
-
-
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-
-
9
9
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-
-
-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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692911
Chen
Residues on the dimer interfac ...
SARS coronavirus
J. Biochem.
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525-536
2008
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-
1
-
7
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-
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2
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1
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1
2
-
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-
1
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7
-
-
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-
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-
-
-
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1
-
-
-
-
1
2
-
-
-
-
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-
-
-
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-
693700
Taranto
QM/QM studies for Michael reac ...
SARS coronavirus
J. Mol. Graph. Model.
27
275-285
2008
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-
-
-
-
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1
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3
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1
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-
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-
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-
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693917
Zhong
Without its N-finger, the main ...
SARS coronavirus
J. Virol.
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2008
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-
-
-
1
-
-
-
-
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3
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-
-
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1
1
1
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-
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1
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-
-
1
1
-
-
-
-
-
-
-
-
-
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-
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693918
Shi
Mechanism for controlling the ...
SARS coronavirus
J. Virol.
82
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2008
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-
1
1
1
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-
-
-
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2
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1
1
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-
1
-
1
1
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-
-
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-
-
-
1
-
-
-
-
-
-
-
-
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678313
Goetz
Substrate specificity profilin ...
SARS coronavirus
Biochemistry
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2007
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1
1
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1
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1
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1
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-
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4
-
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1
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1
-
1
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-
1
1
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1
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
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678690
Ghosh
Structure-based design, synthe ...
SARS coronavirus
Bioorg. Med. Chem. Lett.
17
5876-5880
2007
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-
-
-
-
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7
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1
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-
-
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-
2
-
-
-
-
-
-
-
-
-
-
7
-
-
-
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-
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7
7
-
-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
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678728
Chang
Reversible unfolding of the se ...
SARS coronavirus
Biophys. J.
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2007
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-
-
-
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-
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1
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
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-
-
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679216
Shao
Structure-based design and syn ...
SARS coronavirus
Chembiochem
8
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2007
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-
-
-
-
-
2
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-
-
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1
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1
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2
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2
2
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-
-
-
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-
-
-
-
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681313
Wen
Specific plant terpenoids and ...
SARS coronavirus
J. Med. Chem.
50
4087-4095
2007
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-
-
-
-
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4
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4
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-
1
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-
-
-
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2
-
4
-
-
-
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4
4
2
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-
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-
-
-
-
-
-
-
-
-
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681418
Lee
Crystal structures reveal an i ...
SARS coronavirus
J. Mol. Biol.
366
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2007
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
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-
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681443
Yin
A mechanistic view of enzyme i ...
SARS coronavirus
J. Mol. Biol.
371
1060-1074
2007
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1
1
-
-
2
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2
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1
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-
-
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-
1
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-
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-
-
-
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-
1
-
1
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-
2
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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682785
Zheng
Insight into the activity of S ...
SARS coronavirus
Proteins Struct. Funct. Bioinform.
66
467-479
2007
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-
-
-
-
-
-
-
-
-
-
-
-
2
-
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-
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2
3
-
-
-
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-
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-
-
-
-
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-
-
-
-
2
-
-
-
-
-
-
-
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-
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668633
Graziano
Enzymatic activity of the SARS ...
SARS coronavirus
FEBS Lett.
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2577-2583
2006
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-
1
-
-
-
3
1
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1
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3
-
-
1
-
-
-
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
1
-
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
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678172
Graziano
SARS CoV main proteinase: The ...
SARS coronavirus
Biochemistry
45
14632-14641
2006
-
-
-
-
-
-
-
-
-
-
-
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2
-
-
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-
-
-
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1
2
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-
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-
-
-
1
-
-
-
-
-
-
-
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678512
Hamill
Development of a red-shifted f ...
SARS coronavirus
Biol. Chem.
387
1063-1074
2006
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1
1
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1
1
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-
2
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
1
-
-
-
-
1
1
-
1
-
-
-
-
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-
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1
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-
-
-
2
-
-
-
-
1
-
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678590
Chen
Binding interaction of quercet ...
SARS coronavirus
Bioorg. Med. Chem.
14
8295-8306
2006
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-
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1
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7
2
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1
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-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
1
-
5
7
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
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-
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679164
Wu
Stable benzotriazole esters as ...
SARS coronavirus
Chem. Biol.
13
261-268
2006
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-
-
-
1
-
8
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
1
-
-
8
8
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
-
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679402
Lai
Quaternary structure, substrat ...
SARS coronavirus
Curr. Pharm. Des.
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4555-4564
2006
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-
-
-
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15
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-
-
-
-
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44
-
1
-
-
-
-
2
2
-
-
5
-
10
-
-
-
-
-
-
-
10
15
5
-
-
-
-
-
-
-
-
-
-
-
-
-
44
-
-
-
-
-
2
2
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-
-
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679408
Liang
Characterization and inhibitio ...
SARS coronavirus
Curr. Top. Med. Chem.
6
361-376
2006
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-
-
-
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24
-
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-
-
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4
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-
-
-
-
-
-
2
2
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-
-
-
-
-
-
-
17
-
7
-
-
-
-
-
-
-
7
24
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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679734
Shi
The catalysis of the SARS 3C-l ...
SARS coronavirus
FEBS J.
273
1035-1045
2006
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1
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16
-
-
-
-
-
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-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
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-
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680643
Chen
Only one protomer is active in ...
SARS coronavirus
J. Biol. Chem.
281
13894-13898
2006
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-
-
-
-
-
-
-
-
-
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-
-
2
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-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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681287
Yang
Synthesis, crystal structure, ...
SARS coronavirus
J. Med. Chem.
49
4971-4980
2006
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1
1
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4
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4
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-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
1
-
1
-
-
-
4
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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681289
Lu
Structure-based drug design an ...
SARS coronavirus
J. Med. Chem.
49
5154-5161
2006
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1
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21
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2
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-
1
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-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
21
-
-
-
-
1
-
-
21
21
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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694999
Chu
Rapid peptide-based screening ...
SARS coronavirus
Protein Sci.
15
699-709
2006
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-
-
-
-
-
-
-
-
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1
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3
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-
-
-
-
-
2
-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
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667075
Xu
Structure of the SARS coronavi ...
SARS coronavirus
Acta Crystallogr. Sect. F
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964-966
2005
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1
1
-
-
-
-
-
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-
-
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2
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-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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669868
Tan
pH-dependent conformational fl ...
SARS coronavirus
J. Mol. Biol.
354
25-40
2005
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1
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1
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2
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-
-
-
-
-
-
1
-
1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
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667918
Zhang
Old drugs as lead compounds fo ...
SARS coronavirus
Bioorg. Med. Chem.
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2517-2521
2004
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-
-
-
-
-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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691145
Fan
Biosynthesis, purification, an ...
SARS coronavirus
Biol. Chem.
279
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2004
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1
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-
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6
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3
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1
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-
-
-
-
12
2
1
-
-
1
6
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
1
-
-
-
-
12
2
-
-
1
6
1
1
-
-
-
-
-
-
-
-