Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.62 extracted from

  • Yiang, G.T.; Yu, Y.L.; Hu, S.C.; Chen, M.H.; Wang, J.J.; Wei, C.W.
    PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells (2008), FEBS Lett., 582, 881-885.
    View publication on PubMed
Search for more literature for 3.4.22.62

Inhibitors

Inhibitors Comment Organism Structure
additional information caspase-9/-3 activation in differentiated cells, inhibited by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Homo sapiens caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways caspase-3 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P55211
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell undifferentiated and differentiated cells, differentiation induced by phorbol-12-myristate-13-acetate (TPA) Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 RC-RNase-induced caspase-9/-3-mediated cytotoxicity in undifferentiated and differentiated cells, cell differentiation and adhesion assays, cell proliferation assays, caspase-9/-3-mediated cytotoxicity can be induced in differentiated cells that are pretreated with inhibitors of protein kinase C (PKC) or mitogen activated protein kinase (MEK), caspases-9/-3-mediated cytotoxicity in differentiated cells inhibited by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O i.e. Ac-DEVD-pNA, caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways Homo sapiens acetyl-Asp-Glu-Val-Asp + p-nitroaniline
-
 ?
acetyl-Leu-Glu-His-Asp-p-nitroanilide + H2O i.e. Ac-LEHD-pNA, caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways Homo sapiens acetyl-Leu-Glu-His-Asp + p-nitroaniline
-
 ?
pro-caspase-3 + H2O caspase-9/-3 activation in differentiated cells can be prevented by protein kinase C (PKC) and the mitogen activated protein kinase (MEK) signaling pathways Homo sapiens caspase-3 + ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 caspase activity assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 caspase activity assay at Homo sapiens