Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Mdm2 protein + H2O | Homo sapiens | caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42575 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung adenocarcinoma cell | caspase-2 levels are significantly reduced in human lung adenocarcinoma with wild-type p53 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Mdm2 protein + H2O | - |
Homo sapiens | ? | - |
? | |
Mdm2 protein + H2O | caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53 | Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of caspase-2 leads to enhanced tumor proliferation and progression | Homo sapiens |
physiological function | caspase-2 functions as a tumor suppressor in Kras-driven lung cancer in vivo. Caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53 | Homo sapiens |