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Literature summary for 3.4.22.55 extracted from

  • Pozueta, J.; Lefort, R.; Ribe, E.M.; Troy, C.M.; Arancio, O.; Shelanski, M.
    Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice (2013), Nat. Commun., 4, 1939.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.55

Inhibitors

Inhibitors Comment Organism Structure
amyloid beta treatment of rat hippocampal neuron extracts with either 300 nM or 0.001 mM amyloid beta leads to activation of caspase-2 Rattus norvegicus
VDVAD
-
 Mus musculus
VDVAD
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus P29594
-
-
Rattus norvegicus P55215
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
hippocampus
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
Casp2
-
 Mus musculus
Casp2
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction down-regulation or inactivation of caspase-2 blocks amyloid beta-mediated effects on primary hippocampal cultures Mus musculus
malfunction down-regulation or inactivation of caspase-2 blocks amyloid beta-mediated effects on primary hippocampal cultures Rattus norvegicus
metabolism caspase-2 is a critical mediator in the activation of the RhoA/ROCK-II signaling pathway, leading to the collapse of dendritic spines. Inactive RhoA-GDP but not active RhoA-GTP forms a complex with caspase-2 Mus musculus
metabolism caspase-2 is a critical mediator in the activation of the RhoA/ROCK-II signaling pathway, leading to the collapse of dendritic spines. Inactive RhoA-GDP but not active RhoA-GTP forms a complex with caspase-2 Rattus norvegicus
physiological function caspase-2 plays a critical role in mediating the synaptic changes and memory alteration induced by amyloid beta in Alzheimer's disease Mus musculus
physiological function caspase-2 plays a critical role in mediating the synaptic changes and memory alteration induced by amyloid beta in Alzheimer's disease Rattus norvegicus