Application | Comment | Organism |
---|---|---|
medicine | studies on the role of cathepsin V and cystatin C in the pathophysiology aortic stenosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cystatin C | endogenous inhibitor of cathepsin V analyzed, expression of cystatin C increased in stenotic valves, cystatin C protein particularly found in areas with infiltrates of inflammatory cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60911 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | expression in aorta valve, control valves and stenotic valves analyzed | Homo sapiens | - |
aorta endothelium | cathepsin V localized to endothelial cells in areas rich of neovascularization | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
expression of cathepsin V studied by RT-PCR and immunohistochemistry, cathepsin activity in aortic valves quantified by fluorometric microassay, increased mRNA expression and high activity of cathepsin V in stenotic valves observed, association of cathepsin V and the inhibitor cystatin C with calcific aortic valve disease determined, participation in adverse extracellular matrix remodelling of stenotic aortic valves suggested | Homo sapiens |
additional information | - |
expression of cathepsin V studied by RT-PCR and immunohistochemistry, cathepsin activity quantified by fluorometric microassay, intense association of cathepsin V with neovessels of the stenotic aortic valves reveals a role in neovascularization of the valves | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O | role of cathepsis V and the endogenous inhibitor cystatin C in adverse extracellular matrix remodeling of stenotic aortic valves analyzed | Homo sapiens | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
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