BRENDA - Enzyme Database
show all sequences of 3.4.22.43

Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages

Yasuda, Y.; Li, Z.; Greenbaum, D.; Bogyo, M.; Weber, E.; Broemme, D.; J. Biol. Chem. 279, 36761-36770 (2004)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Pichia pastoris
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
chondroitin 4-sulfate
specific inhibition of elastolytic activity, formation of specific complexes with the enzyme, no inhibition of the activity with Z-Phe-Arg-4-methyl-7-coumaryl amide
Homo sapiens
E-64
-
Homo sapiens
morpholineurea-leucyl-homophenylalanine-vinylsulfone phenyl
-
Homo sapiens
morpholineurea-naphthyl-homophenylalanine-vinylsulfone naphthyl
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0041
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C, in presence of 0.3 M NaCl
Homo sapiens
0.0048
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
intracellular
-
Homo sapiens
5622
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
NaCl
stimulates at 0.3 M
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Elastin + H2O
Homo sapiens
elastin degradation activity leading to loss of elasticity in atherosclerosis
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
proteolytic modification
the recombinant enzyme is activated by pepsin treatment and further purified by gel filtration
Homo sapiens
Purification (Commentary)
Purification (Commentary)
Organism
recombinant enzyme from Pichia pastoris, further purified by gel filtration after activation by pepsin treatment
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
colonic cancer cell
-
Homo sapiens
-
cornea
-
Homo sapiens
-
macrophage
in plaque areas of diseased blood vessels, cathepsin expression levels during differentiation, overview
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
Elastin + H2O
elastin degradation activity leading to loss of elasticity in atherosclerosis
669257
Homo sapiens
?
-
-
-
?
Elastin + H2O
the enzyme exhibits high elastolytic cysteine protease activity
669257
Homo sapiens
?
-
-
-
?
Z-Arg-Arg-4-methoxy-2-nitroanilide + H2O
-
669257
Homo sapiens
Z-Arg-Arg + 4-methoxy-2-nitroaniline
-
-
-
?
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O
-
669257
Homo sapiens
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Homo sapiens
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
37
-
pH 5.5, loss of 60% activity within 20 min
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3.4
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C
Homo sapiens
3.7
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C, in presence of 0.3 M NaCl
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
assay at
Homo sapiens
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
5.5
-
37C, loss of 60% activity within 20 min
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Pichia pastoris
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
chondroitin 4-sulfate
specific inhibition of elastolytic activity, formation of specific complexes with the enzyme, no inhibition of the activity with Z-Phe-Arg-4-methyl-7-coumaryl amide
Homo sapiens
E-64
-
Homo sapiens
morpholineurea-leucyl-homophenylalanine-vinylsulfone phenyl
-
Homo sapiens
morpholineurea-naphthyl-homophenylalanine-vinylsulfone naphthyl
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0041
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C, in presence of 0.3 M NaCl
Homo sapiens
0.0048
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
intracellular
-
Homo sapiens
5622
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
NaCl
stimulates at 0.3 M
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Elastin + H2O
Homo sapiens
elastin degradation activity leading to loss of elasticity in atherosclerosis
?
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
proteolytic modification
the recombinant enzyme is activated by pepsin treatment and further purified by gel filtration
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme from Pichia pastoris, further purified by gel filtration after activation by pepsin treatment
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
colonic cancer cell
-
Homo sapiens
-
cornea
-
Homo sapiens
-
macrophage
in plaque areas of diseased blood vessels, cathepsin expression levels during differentiation, overview
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
Elastin + H2O
elastin degradation activity leading to loss of elasticity in atherosclerosis
669257
Homo sapiens
?
-
-
-
?
Elastin + H2O
the enzyme exhibits high elastolytic cysteine protease activity
669257
Homo sapiens
?
-
-
-
?
Z-Arg-Arg-4-methoxy-2-nitroanilide + H2O
-
669257
Homo sapiens
Z-Arg-Arg + 4-methoxy-2-nitroaniline
-
-
-
?
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O
-
669257
Homo sapiens
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Homo sapiens
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
37
-
pH 5.5, loss of 60% activity within 20 min
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3.4
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C
Homo sapiens
3.7
-
Z-Phe-Arg-4-methyl-7-coumaryl amide
recombinant enzyme, pH 5.5, 25C, in presence of 0.3 M NaCl
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
assay at
Homo sapiens
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
5.5
-
37C, loss of 60% activity within 20 min
Homo sapiens
Other publictions for EC 3.4.22.43
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
753977
Mons
The Alkyne moiety as a latent ...
Homo sapiens
J. Am. Chem. Soc.
141
3507-3514
2019
-
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752678
Homma
Melanosome degradation in epi ...
Homo sapiens
Biochem. Biophys. Res. Commun.
500
339-343
2018
-
-
-
-
1
-
1
-
2
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
753117
Leng
L-Homocysteine-induced cathep ...
Homo sapiens
Br. J. Pharmacol.
175
1157-1172
2018
-
-
1
-
-
-
1
-
2
-
-
-
-
4
-
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2
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1
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1
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1
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1
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2
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-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
2
3
3
2
-
-
753828
Huang
Exogenous cathepsin V protein ...
Homo sapiens
Int. J. Biochem. Cell Biol.
89
6-15
2017
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
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-
1
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-
-
1
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-
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-
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-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
752418
Naumnik
Endostatin and cathepsin-V in ...
Homo sapiens
Adv. Exp. Med. Biol.
833
55-61
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
-
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
754753
Pribis
The HIV protease inhibitor sa ...
Homo sapiens
Mol. Med.
21
749-757
2015
-
1
-
-
1
-
5
-
1
-
-
1
-
4
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
5
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
732591
Wong
CTSL2 is a pro-apoptotic targe ...
Homo sapiens
Oncogene
33
1249-1257
2014
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
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-
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-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
731213
McCarthy
-
Cathepsin L proteases of the p ...
Lepeophtheirus salmonis
Aquaculture
356-357
264-271
2012
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
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-
1
2
-
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731573
Skrzypczak
Expression of cysteine proteas ...
Homo sapiens
Cancer Invest.
30
398-403
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
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2
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
732049
Funkelstein
Human cathepsin V protease par ...
Homo sapiens
J. Biol. Chem.
287
15232-15241
2012
-
-
-
-
-
-
-
-
1
-
1
2
-
3
-
-
-
-
-
4
-
-
5
1
2
-
-
-
-
-
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-
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-
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-
1
-
1
2
-
-
-
-
-
4
-
-
5
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
732502
Keegan
Tumor necrosis factor alpha st ...
Homo sapiens
Mol. Cell. Biochem.
367
65-72
2012
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
3
-
-
1
1
-
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1
1
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3
-
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1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
732867
Novinec
A simple and efficient protoco ...
Homo sapiens
Protein Expr. Purif.
82
1-5
2012
1
-
1
-
-
-
1
2
-
-
1
1
-
2
-
-
1
-
-
-
-
-
4
1
-
-
-
-
2
-
-
-
-
-
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-
1
-
1
-
-
-
-
-
1
-
2
-
-
1
1
-
-
-
1
-
-
-
-
4
1
-
-
-
2
-
-
-
-
-
-
-
-
2
2
717159
Wilder
Manipulating substrate and pH ...
Homo sapiens
Arch. Biochem. Biophys.
516
52-57
2011
-
-
1
-
-
-
1
-
-
-
2
1
-
2
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
717374
Severino
Acridone alkaloids as potent i ...
Homo sapiens
Bioorg. Med. Chem.
19
1477-1481
2011
-
-
1
-
-
-
11
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
9
-
11
-
-
1
-
-
-
-
11
11
9
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717375
Piovan
Structure-activity relationshi ...
Homo sapiens
Bioorg. Med. Chem.
19
2009-2014
2011
-
-
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707590
Elie
Identification and pre-clinica ...
Homo sapiens
Biochimie
92
1618-1624
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
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-
1
-
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-
-
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1
1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707591
Sevenich
Expression of human cathepsin ...
Homo sapiens
Biochimie
92
1674-1680
2010
-
-
1
-
-
-
-
-
-
-
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1
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