BRENDA - Enzyme Database
show all sequences of 3.4.22.43

Cathepsin V

Broemme, D.; Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D., Woessner, J.F., eds) 2nd Ed., 1107-1109 (2004)
No PubMed abstract available

Data extracted from this reference:

Application
Application
Commentary
Organism
diagnostics
the enzyme is a potential marker for certain colon tumors and breast cancer
Homo sapiens
Cloned(Commentary)
Commentary
Organism
from cDNA libraries, the gene maps to chromosome 9q21, DNA and amino acid sequence determination and analysis, genomic organization, expression in insect cells using the baculovirus system, in Pichia pastoris, and as GST-tagged enzyme with low activity in Escherichia coli
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
Calpeptin
-
Homo sapiens
cystatins
-
Homo sapiens
E-64
-
Homo sapiens
leupeptin
-
Homo sapiens
peptidl vinyl sulfones
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
the enzyme is secreted
Homo sapiens
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
23999
-
2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris
Homo sapiens
31000
-
2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris
Homo sapiens
52000
-
recombinant GST-tagged enzyme
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
glycoprotein
N-glycosylation of extracellular proenzyme and mature enzyme
Homo sapiens
proteolytic modification
autoactivation of the inactive extracellular zymogen at pH 4.0 and 37°C to the active mature protein
Homo sapiens
Purification (Commentary)
Commentary
Organism
recombinant enzyme from Pichia pastoris to homogeneity, activated mature native enzyme by hyrophobic interaction chromatography, recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cornea
epithelium
Homo sapiens
-
epithelium
thymic and corneal
Homo sapiens
-
additional information
selective, tissue-specific expression
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
epithelium
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Albumin + H2O
-
668763
Homo sapiens
?
-
-
-
?
MHC class II-associated invariant chain + H2O
-
668763
Homo sapiens
?
-
-
-
?
additional information
the enzyme prefers hydrophobic residues in its S2-binding pocket, the substrate specificity is similar to cathepsin L, no cleavage of the triple-helical region of native collagen
668763
Homo sapiens
?
-
-
-
-
Type I collagen + H2O
cleavage of telopeptide region
668763
Homo sapiens
?
-
-
-
?
Z-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
668763
Homo sapiens
Z-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
668763
Homo sapiens
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris
Homo sapiens
More
three-dimensional two-domain structure analysis at 1.6 A resolution, overview
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6
-
Homo sapiens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
additional information
-
bell-shaped pH profile
Homo sapiens
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
additional information
-
rapid loss of activity at neutral pH
Homo sapiens
4.5
5.5
very stable
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
diagnostics
the enzyme is a potential marker for certain colon tumors and breast cancer
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
from cDNA libraries, the gene maps to chromosome 9q21, DNA and amino acid sequence determination and analysis, genomic organization, expression in insect cells using the baculovirus system, in Pichia pastoris, and as GST-tagged enzyme with low activity in Escherichia coli
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Calpeptin
-
Homo sapiens
cystatins
-
Homo sapiens
E-64
-
Homo sapiens
leupeptin
-
Homo sapiens
peptidl vinyl sulfones
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
the enzyme is secreted
Homo sapiens
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
23999
-
2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris
Homo sapiens
31000
-
2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris
Homo sapiens
52000
-
recombinant GST-tagged enzyme
Homo sapiens
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
glycoprotein
N-glycosylation of extracellular proenzyme and mature enzyme
Homo sapiens
proteolytic modification
autoactivation of the inactive extracellular zymogen at pH 4.0 and 37°C to the active mature protein
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme from Pichia pastoris to homogeneity, activated mature native enzyme by hyrophobic interaction chromatography, recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cornea
epithelium
Homo sapiens
-
epithelium
thymic and corneal
Homo sapiens
-
additional information
selective, tissue-specific expression
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
epithelium
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Albumin + H2O
-
668763
Homo sapiens
?
-
-
-
?
MHC class II-associated invariant chain + H2O
-
668763
Homo sapiens
?
-
-
-
?
additional information
the enzyme prefers hydrophobic residues in its S2-binding pocket, the substrate specificity is similar to cathepsin L, no cleavage of the triple-helical region of native collagen
668763
Homo sapiens
?
-
-
-
-
Type I collagen + H2O
cleavage of telopeptide region
668763
Homo sapiens
?
-
-
-
?
Z-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
668763
Homo sapiens
Z-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
668763
Homo sapiens
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris
Homo sapiens
More
three-dimensional two-domain structure analysis at 1.6 A resolution, overview
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
6
-
Homo sapiens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
additional information
-
bell-shaped pH profile
Homo sapiens
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
additional information
-
rapid loss of activity at neutral pH
Homo sapiens
4.5
5.5
very stable
Homo sapiens
Other publictions for EC 3.4.22.43
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732591
Wong
CTSL2 is a pro-apoptotic targe ...
Homo sapiens
Oncogene
33
1249-1257
2014
-
-
-
-
-
-
-
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1
-
-
-
-
2
-
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5
-
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1
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5
-
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-
-
-
-
1
2
2
1
-
-
731213
McCarthy
-
Cathepsin L proteases of the p ...
Lepeophtheirus salmonis
Aquaculture
356-357
264-271
2012
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
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1
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1
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-
1
-
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-
-
-
-
-
-
-
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-
-
-
731573
Skrzypczak
Expression of cysteine proteas ...
Homo sapiens
Cancer Invest.
30
398-403
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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2
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2
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-
-
-
-
-
-
1
-
-
1
-
-
732049
Funkelstein
Human cathepsin V protease par ...
Homo sapiens
J. Biol. Chem.
287
15232-15241
2012
-
-
-
-
-
-
-
-
1
-
1
2
-
3
-
-
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-
-
4
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-
5
1
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1
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1
2
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-
4
-
-
5
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
732502
Keegan
Tumor necrosis factor alpha st ...
Homo sapiens
Mol. Cell. Biochem.
367
65-72
2012
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
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-
1
1
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
732867
Novinec
A simple and efficient protoco ...
Homo sapiens
Protein Expr. Purif.
82
1-5
2012
1
-
1
-
-
-
1
2
-
-
1
1
-
2
-
-
1
-
-
-
-
-
4
1
-
-
-
2
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
2
-
-
1
1
-
-
-
1
-
-
-
-
4
1
-
-
-
2
-
-
-
-
-
-
-
-
2
2
717159
Wilder
Manipulating substrate and pH ...
Homo sapiens
Arch. Biochem. Biophys.
516
52-57
2011
-
-
1
-
-
-
1
-
-
-
2
1
-
2
-
1
-
-
-
-
-
-
1
1
-
-
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-
-
1
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-
1
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-
1
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-
-
2
1
-
-
1
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-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
717374
Severino
Acridone alkaloids as potent i ...
Homo sapiens
Bioorg. Med. Chem.
19
1477-1481
2011
-
-
1
-
-
-
11
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
9
-
11
-
-
1
-
-
-
-
11
11
9
-
1
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
717375
Piovan
Structure-activity relationshi ...
Homo sapiens
Bioorg. Med. Chem.
19
2009-2014
2011
-
-
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
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-
-
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6
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707590
Elie
Identification and pre-clinica ...
Homo sapiens
Biochimie
92
1618-1624
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
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1
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1
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1
1
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1
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-
-
-
-
707591
Sevenich
Expression of human cathepsin ...
Homo sapiens
Biochimie
92
1674-1680
2010
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
4
-
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1
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1
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1
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4
-
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1
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-
-
-
-
-
-
-
1
1
-
-
-
707626
Coppini
Plasminogen hydrolysis by cath ...
Homo sapiens
Biol. Chem.
391
561-570
2010
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
7
-
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-
-
-
-
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1
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1
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-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
6
6
709133
Renko
Versatile loops in mycocypins ...
Homo sapiens
J. Biol. Chem.
285
308-316
2010
-
-
1
1
-
-
2
-
-
-
-
-
-
3
-
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2
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1
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1
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2
2
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-
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-
707906
Cheng
The cystatin M/E-controlled pa ...
Homo sapiens
Br. J. Dermatol.
161
253-264
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
709405
Zeeuwen
The biology of cystatin M/E an ...
Homo sapiens
J. Invest. Dermatol.
129
1327-1338
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
3
-
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1
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1
1
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-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
683210
Puzer
Cathepsin V, but not cathepsin ...
Homo sapiens
Biol. Chem.
389
195-200
2008
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
1
1
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2
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1
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1
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1
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-
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1
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1
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
698753
Mihelic
Inhibitory fragment from the p ...
Homo sapiens
J. Biol. Chem.
283
14453-14460
2008
-
-
-
1
-
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1
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-
-
-
-
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1
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1
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1
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1
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1
1
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1
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-
-
-
683207
Burden
Inhibition of cathepsin L-like ...
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2007
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683662
Ong
DNA accelerates the inhibition ...
Homo sapiens
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669460
Cheng
Cystatin M/E is a high affinit ...
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669754
Zeeuwen
Colocalization of cystatin M/E ...
Homo sapiens
J. Invest. Dermatol.
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120-128
2006
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683107
Helske
Increased Expression of Elasto ...
Homo sapiens
Arterioscler. Thromb. Vasc. Biol.
26
1791-1798
2006
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669009
Kenney
Increased levels of catalase a ...
Homo sapiens
Invest. Ophthalmol. Vis. Sci.
46
823-832
2005
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667305
Puzer
Comparative substrate specific ...
Homo sapiens
Arch. Biochem. Biophys.
430
274-283
2004
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8
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12
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668472
Hagemann
The human cysteine protease ca ...
Homo sapiens
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83
775-780
2004
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668763
Broemme
-
Cathepsin V ...
Homo sapiens
Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D., Woessner, J.F., eds)
2nd Ed.
1107-1109
2004
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2
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669257
Yasuda
Cathepsin V, a novel and poten ...
Homo sapiens
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36761-36770
2004
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137272
Somoza
Crystal structure of human cat ...
Homo sapiens
Biochemistry
39
12543-12551
2000
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137269
Brömme
Human cathepsin V functional e ...
Homo sapiens
Biochemistry
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2377-2385
1999
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137270
Adachi
Isolation and characterization ...
Homo sapiens
Invest. Ophthalmol. Vis. Sci.
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1789-1796
1998
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137271
Santamaria
Cathepsin L2, a novel human cy ...
Homo sapiens
Cancer Res.
58
1624-1630
1998
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