Literature summary for 3.4.21.B25 extracted from

Tsuji, A.; Kikuchi, Y.; Sato, Y.; Koide, S.; Yuasa, K.; Nagahama, M.; Matsuda, Y.
A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4 (2006), Biochem. J., 396, 51-59.

Search for more literature for 3.4.21.B25

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	selective and transient association of reticulocalbin-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4	Homo sapiens
reticulocalbin-3	efficiency of PACE4 secretion increases 2fold by coexpression with wild type reticulocalbin-3	Homo sapiens

Application

Application	Comment	Organism
additional information	selective and transient association of reticulocalbin-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
A23187	if reticulocalbin-3 binds to proPACE4 transiently during its biosynthesis, this Ca2+-specific ionophore can block the maturation of proPACE4 to PACE4, accumulation of the proPaCE4-recticulocalbin-3 complex in the cells	Homo sapiens
alpha1-antitrypsin variant RVRR	-	Homo sapiens
Ca2+	Ca2+ ionophore inhibits protein maturation	Homo sapiens
reticulocalbin-1	reduces efficiency of PACE4 secretion by 21%	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
110000	-	SDS-PAGE, proPACE4	Homo sapiens
110000	-	pre-mature protein, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryonic kidney cell line	-	Homo sapiens	-
HEK-293 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PACE 4	-	Homo sapiens
PACE4	-	Homo sapiens
paired basic amino-acid-cleaving enzyme-4	-	Homo sapiens

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Release 2023.1 (January 2023)