Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B25 extracted from

  • Tsuji, A.; Ikoma, T.; Hashimoto, E.; Matsuda, Y.
    Development of selectivity of alpha1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition (2002), Protein Eng., 15, 123-130.
    View publication on PubMed
Search for more literature for 3.4.21.B25

Cloned(Commentary)

Cloned (Comment) Organism
isoform PACE4A-I Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-antitrypsin variant AVRR 50% inhibition above 0.002 mM Homo sapiens
alpha1-antitrypsin variant PDX 50% inhibition above 0.00002 mM, forms a complex with the enzyme Homo sapiens
alpha1-antitrypsin variant RVRR 50% inhibition at 0.000005 mM, forms a complex with the enzyme Homo sapiens
EDTA 85% inhibition at 20 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-complement C3 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroglutamyl-RTKR-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
pro-complement C3 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PACE4
-
 Homo sapiens